Characterization of In Vivo Retinal Lesions of Diabetic Retinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy

International Journal of Endocrinology
Sonja G KarstJennifer K Sun

Abstract

To characterize hallmark diabetic retinopathy (DR) lesions utilizing adaptive optics scanning laser ophthalmoscopy (AOSLO) and to compare AOSLO findings with those on standard imaging techniques. Cross-sectional study including 35 eyes of 34 study participants. AOSLO confocal and multiply scattered light (MSL) imaging were performed in eyes with DR. Color fundus photographs (CF), infrared images of the macula (Spectralis, Heidelberg), and Spectralis spectral domain optical coherence tomography SDOCT B-scans of each lesion were obtained and registered to corresponding AOSLO images. Individual lesion characterization by AOSLO imaging. AOSLO appearance was compared with CF and SDOCT imaging. Characterized lesions encompassed 52 microaneurysms (MA), 20 intraretinal microvascular abnormalities (IRMA), 7 neovascularization (NV), 11 hard exudates (HE), 5 dot/blot hemorrhages (HEM), 4 cotton wool spots (CWS), and 14 intraretinal cysts. AOSLO allowed assessment of perfusion in vascular lesions and enabled the identification of vascular lesions that could not be visualized on CF or SDOCT. AOSLO imaging provides detailed, noninvasive in vivo visualization of DR lesions enhancing the assessment of morphological characteristics. These uniqu...Continue Reading

References

Apr 1, 1995·The British Journal of Ophthalmology·A W StittD B Archer
Nov 14, 1997·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·J LiangD T Miller
Sep 1, 1961·Archives of Ophthalmology·D G COGANT KUWABARA
Jan 1, 1962·Archives of Ophthalmology·D TOUSSAINTT KUWABARA
Jan 2, 2004·The New England Journal of Medicine·Robert N Frank
Oct 22, 2004·Applied Optics·Robert H WebbStephen A Burns
Mar 11, 2006·Journal of Biomedical Optics·Yuhua Zhang, Austin Roorda
Apr 13, 2007·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Stephen A BurnsDaniel X Hammer
Apr 13, 2007·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Robert J ZawadzkiJohn S Werner
Apr 13, 2007·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Ann E ElsnerMasahiro Miura
May 5, 2009·Ophthalmology·Matthias BolzUNKNOWN Diabetic Retinopathy Research Group Vienna
May 6, 2002·Optics Express·Austin RoordaMelanie Campbell
Jan 28, 2010·American Journal of Ophthalmology·Daniel F KiernanSeenu M Hariprasad
Apr 15, 1987·Applied Optics·R H WebbF C Delori
Sep 22, 2010·American Journal of Ophthalmology·Takahiro HoriiNagahisa Yoshimura
Nov 9, 2010·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Pooja GodaraJoseph Carroll
Mar 11, 2011·Eye·D T MillerS Lee
Jan 4, 2012·Diabetes Care·UNKNOWN American Diabetes Association
Jan 13, 2012·Diabetes Care·Jerry D CavalleranoLloyd P Aiello
Feb 23, 2013·Current Opinion in Ophthalmology·Mehreen Adhi, Jay S Duker
Apr 30, 2013·Current Eye Research·Joseph CarrollMarco Lombardo
Sep 28, 2013·Investigative Ophthalmology & Visual Science·Toco Y P ChuiStephen A Burns
Jan 16, 2014·Investigative Ophthalmology & Visual Science·Michael DubowRichard B Rosen
Jan 25, 2016·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Toco Yuen Ping ChuiRichard B Rosen
Feb 16, 2016·Ophthalmic Surgery, Lasers & Imaging Retina·Talisa E de CarloNadia K Waheed
May 20, 2016·Journal of Ophthalmic & Vision Research·K V Chalam, Kumar Sambhav
Nov 17, 2016·International Journal of Retina and Vitreous·Toco Y P ChuiRichard B Rosen

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Citations

Mar 13, 2020·Brain : a Journal of Neurology·Iris KleerekooperS Anand Trip
Dec 5, 2019·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Phillip Bedggood, Andrew Metha
Jul 3, 2020·International Journal of Retina and Vitreous·Sara Vaz-PereiraRaquel Esteves Marques
Jul 9, 2021·Frontiers in Pharmacology·Annagrazia AdornettoRossella Russo
Feb 25, 2021·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Chui Ming Gemmy CheungSobha Sivaprasad

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Methods Mentioned

BETA
imaging technique
imaging techniques

Software Mentioned

AOSLO
ImageJ
Matlab

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