Characterization of influenza A (H7N9) viruses isolated from human cases imported into Taiwan

PloS One
Ji-Rong YangMing-Tsan Liu

Abstract

A novel avian influenza A (H7N9) virus causes severe human infections and was first identified in March 2013 in China. The H7N9 virus has exhibited two epidemiological peaks of infection, occurring in week 15 of 2013 and week 5 of 2014. Taiwan, which is geographically adjacent to China, faces a large risk of being affected by this virus. Through extensive surveillance, launched in April 2013, four laboratory-confirmed H7N9 cases imported from China have been identified in Taiwan. The H7N9 virus isolated from imported case 1 in May 2013 (during the first wave) was found to be closest genetically to a virus from wild birds and differed from the prototype virus, A/Anhui/1/2013, in the MP gene. The other three imported cases were detected in December 2013 and April 2014 (during the second wave). The viruses isolated from cases 2 and 4 were similar in the compositions of their 6 internal genes and distinct from A/Anhui/1/2013 in the PB2 and MP genes, whereas the virus isolated from case 3 exhibited a novel reassortment that has not been identified previously and was different from A/Anhui/1/2013 in the PB2, PA and MP genes. The four imported H7N9 viruses share similar antigenicity with A/Anhui/1/2013, and their HA and NA genes group...Continue Reading

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Citations

Dec 2, 2015·PloS One·Qiuyan LiaoRichard Fielding
Mar 6, 2017·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Ji-Rong Yang, Ming-Tsan Liu
Feb 26, 2016·Journal of Virology·Jessica A BelserTerrence M Tumpey
Sep 22, 2017·The Journal of Infectious Diseases·Larisa V GubarevaJames Stevens
Jun 8, 2017·International Journal of Molecular Sciences·Christine L P EngTin Wee Tan
Nov 2, 2019·Journal of Biological Engineering·Chia-Chun LaiAlan Yung-Chih Hu

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Methods Mentioned

BETA
PCR

Software Mentioned

MEGA5
Sequencher

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