Characterization of inhibin/activin subunit, follistatin, and activin type II receptors in human ovarian cancer cell lines: a potential role in autocrine growth regulation

Endocrinology
N Di SimoneA Schneyer

Abstract

Although ovarian cancer is the most common gynecological malignancy with a relatively poor 5-yr survival record, the mechanism(s) by which these tumors arise is not well understood. A role for inhibins and activins in regulating this transformation is suggested by the detection of circulating alpha or dimeric inhibin in some patients with ovarian cancer and by the alpha inhibin knockout mouse, in which development of gonadal tumors in 100% of homozygotes is associated with greatly elevated activin levels. To develop diagnostic tools with greater specificity for ovarian cancers, the present study was targeted at characterizing the biosynthetic capacity of the epithelial ovarian cancer cell lines from the American Type Culture Collection with respect to inhibin, activin, the related activin-binding protein follistatin (FS), and activin receptor type II. In addition, the functional capacity of this system was investigated by examining the ability of activin and FS to modulate cellular proliferation. All six cell lines contained abundant messenger RNA (mRNA) for activin receptor type II, but no inhibin alpha-subunit mRNA was detected in any cell line. Two cell lines contained mRNA for activin beta B-subunit (CaOV4 and SKOV3), one c...Continue Reading

Citations

Sep 25, 2009·Molecular & Cellular Proteomics : MCP·Chris PlanqueEleftherios P Diamandis
Jun 23, 2010·Reproductive Biology and Endocrinology : RB&E·Saneal RajanahallyQinglei Li
May 3, 2008·Endocrinology·Thuy-Vy DoTeresa K Woodruff
Mar 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T ShutoM E Bolander
Apr 25, 2000·Molecular and Cellular Endocrinology·I PezzaniF Petraglia
Oct 3, 2007·Annals of Surgical Oncology·Keiji YoshinagaMasaki Mori
Aug 16, 2011·Molecular and Cellular Endocrinology·Ann E Drummond, Peter J Fuller
Feb 24, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ioannis MylonasKlaus Friese
Aug 19, 2015·Molecular and Cellular Endocrinology·Karen L Reader, Elspeth Gold
Feb 13, 1999·American Journal of Obstetrics and Gynecology·K YamashitaR Nakano
May 18, 1999·Gynecologic Oncology·P J FullerH G Burger
Jul 1, 1999·Gynecologic Oncology·G M Lambert-MesserlianW H Gajewski
Aug 22, 2001·Biology of Reproduction·A J DulebaR Z Spaczynski
Sep 9, 2011·Biology of Reproduction·Xiaohui LiStephanie A Pangas
Aug 22, 2012·The Journal of International Medical Research·P RenY-N Wang
Oct 12, 2010·The Journal of International Medical Research·D F ZhangQ L Meng
Aug 26, 1998·International Journal of Cancer. Journal International Du Cancer·J KleeffM Korc
Apr 2, 1998·Histopathology·M Wells
Aug 31, 2002·Molecular Carcinogenesis·Walter RossmanithRolf Schulte-Hermann
Oct 9, 2002·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S DepasqualeU Tantravahi
Mar 19, 2002·Endocrinology·Lesley D DunfieldMark W Nachtigal
Oct 31, 2006·Human Reproduction Update·Peter C K Leung, Jung-Hye Choi
Dec 12, 2001·Endocrine Reviews·G P RisbridgerD M Robertson
Apr 11, 2001·Endocrine Reviews·N AuerspergP C Leung
Oct 16, 2015·Applied Immunohistochemistry & Molecular Morphology : AIMM·Geralyn Lambert-MesserlianRichard Moore
Apr 30, 2021·Acta Biomaterialia·Anna StejskalováBenjamin D Almquist
Dec 31, 1998·Life Sciences·J FukudaP C Leung

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.