Characterization of inhibition by haloperidol and chlorpromazine of a voltage-activated K+ current in rat phaeochromocytoma cells

British Journal of Pharmacology
K NakazawaK Inoue

Abstract

1. Inhibition by haloperidol and chlorpromazine of a voltage-activated K+ current was characterized in rat phaeochromocytoma PC12 cells by use of whole-cell voltage-clamp techniques. 2. Haloperidol or chlorpromazine (1 and 10 microM) inhibited a K+ current activated by a test potential of +20 mV applied from a holding potential of -60 mV. The K+ current inhibition did not exhibit voltage-dependence when test potentials were changed between -10 and +40 mV or when holding potentials were changed between -120 and -60 mV. 3. Effects of compounds that are related to haloperidol and chlorpromazine in their pharmacological actions were examined. Fluspirilene (1 and 10 microM), an antipsychotic drug, inhibited the K+ current, but pimozide (1 and 10 microM), another antipsychotic drug did not significantly inhibit the K+ current. Sulpiride (1 or 10 microM), an antagonist of dopamine D2 receptors, did not affect the K+ current whereas (+)-SCH-23390 (10 microM), an antagonist of dopamine D1 receptors, reduced the K+ current. As for calmodulin antagonists, W-7 (100 microM), but not calmidazolium (1 microM), reduced the K+ current. 4. The inhibition by haloperidol or chlorpromazine of the K+ current was abolished when GTP in intracellular s...Continue Reading

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Citations

Aug 4, 2004·Progress in Biophysics and Molecular Biology·William BainsCat White
Aug 1, 2000·European Journal of Pharmacology·J C DreixlerK M Houamed
Oct 24, 1996·European Journal of Pharmacology·K ItoK Inoue
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Nov 30, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·O KontkanenE Castrén
Feb 26, 2011·The Journal of Parasitology·David G GoodwinDavid S Lindsay
Apr 24, 2014·European Journal of Pharmacology·Hua-Juan LiZhi Qi
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Dec 15, 2005·Toxicology and Applied Pharmacology·Juan A OrellanaJuan C Sáez
Oct 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Mieke NysChris Ulens
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Dec 18, 2010·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Su-Hyun Jo, So-Young Lee

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