PMID: 8592122Feb 1, 1996Paper

Characterization of insulin-like growth factor-I and its receptor and binding proteins in transected nerves and cultured Schwann cells

Journal of Neurochemistry
H L ChengE L Feldman

Abstract

The insulin-like growth factors (IGFs) are trophic factors whose growth-promoting actions are mediated via the IGF-I receptor and modulated by six IGF binding proteins (IGFBPs). In this study, we observed increased transcripts of both IGF-I and IGF-I receptor after rat sciatic nerve transection. Schwann cells (SCs) were the main source of IGF-I and IGFBP-5 immunoreactivity until 7 days after nerve transection, when invading macrophages in the distal nerve stumps were strongly IGF-I positive. In vitro, IGF-I promoted SC mitogenesis. Northern analysis revealed that SCs expressed IGF-I receptor and IGFBP-5. IGF-I treatment increased the intensity of IGFBP-5 without affecting gene expression. Des(1-3)IGF-I, an IGF-I analogue with low affinity for IGFBP, had no such effect. Incubation of recombinant human IGFBP-5 with SC conditioned media revealed IGF-I protection of IGFBP-5 from proteolysis, implying the presence of an IGFBP-5 protease in SC conditioned media. Collectively, these data support the concept that, in response to nerve injury, invading macrophages produce IGF-I and SC express the IGF-I receptor, to facilitate regeneration. This regenerative process may be augmented further by the ability of SC to secrete IGFBPs, which i...Continue Reading

Citations

Dec 10, 1999·Journal of Neurobiology·C L DelaneyE L Feldman
Nov 30, 2005·Journal of Biomedical Materials Research. Part a·Chun-Yuan ChengYueh-Sheng Chen
Apr 12, 2006·The Journal of International Medical Research·R Godińez-GómezC Vásquez
Nov 7, 2006·Neuropathology and Applied Neurobiology·C O HanemannT Utermark
Aug 23, 2008·Endocrinology·Kelli A SullivanEva L Feldman
Sep 17, 2013·The Journal of Urology·Yasuhiro SuminoNaoki Yoshimura
Jun 10, 2020·The Journal of Physiological Sciences : JPS·Motoyasu SugiyamaSeiji Kakehata
Jul 20, 2000·Journal of Neuropathology and Experimental Neurology·J W RussellD Golovoy
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·F Hefti
May 22, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hsien-Tung ChenYueh-Sheng Chen
Oct 16, 2004·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Shigeko Fushimi, Teruo Shirabe
Dec 17, 2008·Antioxidants & Redox Signaling·Andrea M VincentEva L Feldman
Jun 8, 2011·Nature Reviews. Neurology·Sylwia Ammoun, C Oliver Hanemann
Jul 22, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sadaoki SakaiKoichi Endo
Jan 1, 2013·Brain Sciences·Asa Fex Svennigsen, Lars B Dahlin
Nov 18, 2017·International Journal of Molecular Sciences·Vittorio Emanuele BianchiLaura Rizzi
Apr 29, 1999·Brain Pathology·G Stoll, H W Müller
May 1, 1997·Journal of Cellular Physiology·H L Cheng, E L Feldman
Sep 1, 2005·Endocrine Reviews·V C RussoG A Werther
Apr 10, 2004·Neurological Research·Eric D Rabinovsky
Jul 21, 2005·Thyroid : Official Journal of the American Thyroid Association·Jamie C Mitchell, Sareh Parangi
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May 19, 2016·Expert Opinion on Therapeutic Targets·Sami H TuffahaGerald Brandacher
Oct 1, 1999·Annals of the New York Academy of Sciences·Hsin-Lin ChengEva L Feldman
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Jan 1, 1997·Neurobiology of Disease·E L FeldmanJ W Russell

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