Characterization of interferons induced by bacteria and interferon-producing leukocytes in human peripheral blood.

Infection and Immunity
L RönnblomG V Alm

Abstract

All of 23 different preparations of formaldehyde-fixed and heat-killed bacteria induced the appearance of high levels of interferon (IFN) in cultures of human peripheral blood mononuclear leukocytes. Some bacteria induced peak IFN titers after 24 h of culture, whereas other bacteria showed maximal titers on culture days 2 to 3. The IFN displayed various properties. One type, which appeared early during the cultures, had characteristics of IFN-alpha, being resistant to pH 2 treatment but neutralized by antibodies to IFN-alpha. A second type, which appeared later, on culture days 2 to 3, resembled IFN-gamma in being sensitive to pH 2 treatment but resistant to anti-IFN-alpha antibodies. A third type, which appeared to be sensitive to both pH 2 and antibody treatment, was interpreted as atypical IFN-alpha. The application of cell fractionation procedures indicated that nonadherent, predominantly Fc receptor-bearing, non-T, non-B cells were producers of IFN-alpha as defined by its antigenic properties. They copurified approximately with cells carrying natural killer activity toward human erythroid leukemia K562 cells. Some bacteria apparently also stimulated T lymphocytes to produce material with properties of IFN-gamma.

References

Oct 1, 1979·Infection and Immunity·W R FleischmannH M Johnson
Jan 1, 1978·Scandinavian Journal of Immunology·G Banck, A Forsgren
Mar 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·P LindahlI Gresser
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Feb 1, 1981·Journal of Interferon Research·M Wiranowska-Stewart, W E Stewart
Apr 24, 1981·Science·W A Nelson-ReesR R Flandermeyer
Mar 15, 1980·International Journal of Cancer. Journal International Du Cancer·I RiesenfeldH Wigzell
Aug 1, 1964·Klinische Wochenschrift·R FISCHER, F SCHMALZL

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Citations

Sep 3, 2011·Immunological Reviews·Yaming WangMarco Colonna
Mar 1, 1984·Acta paediatrica Scandinavica·B D BhatiaV Bhargava
Nov 18, 2004·Immunological Reviews·Christian BogdanUlrike Schleicher
Jan 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·H SvenssonG Alm
Jun 1, 1983·European Journal of Immunology·L RönnblomG V Alm
Jun 7, 2014·Frontiers in Immunology·Isabelle Bekeredjian-DingMarijo Parcina
Mar 1, 1984·Acta paediatrica Scandinavica·M BondestamT Foucard
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marijo ParcinaIsabelle Bekeredjian-Ding

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