Characterization of interstitial nephritis in pigs with naturally occurring postweaning multisystemic wasting syndrome

Veterinary Pathology
G SarliP S Marcato

Abstract

Kidney samples with interstitial nephritis from 26 pigs affected by postweaning multisystemic wasting syndrome (PMWS) were selected. A histologic evaluation was carried out to describe the type of inflammation and its relationship with viral load, as assessed by in situ hybridization (ISH). Of 26 cases, 10 revealed a tubulointerstitial, lymphoplasmacytic nephritis, 11 an interstitial granulomatous nephritis, and 5 both types of inflammation (mixed type). In 4 cases of granulomatous inflammation, the pattern was not classically nodular, and a population of macrophages and lymphocytes was present (interstitial lymphohistiocytic nephritis). ISH confirmed the presence of porcine circovirus type 2 (PCV2) nucleic acid in all cases. The epithelium of the renal tubules was the most constantly ISH-positive structure. In tubulointerstitial nephritis, the higher the number of positive inflammatory cells, the more severe the inflammation. The ISH reaction was more heterogeneous and unpredictable in granulomatous nephritis, with some epithelioid and giant cells positive by ISH. To quantify macrophages distributed in the three patterns of nephritis, immunohistochemical methods using anti-major histocompatibility complex II (anti-MHC-II) and ...Continue Reading

References

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Citations

May 1, 2013·Emerging Infectious Diseases·Linlin LiPatricia A Pesavento
Jan 10, 2012·Veterinary Immunology and Immunopathology·M PezzolatoE Radaelli
Sep 29, 2015·Clinical Kidney Journal·Mirna Aleckovic-HalilovicAlexander Woywodt
Jun 14, 2012·Veterinary Pathology·T Opriessnig, I Langohr
Sep 8, 2017·Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere·Ines SpiekermeierWolfgang Baumgärtner

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