Characterization of intracranial atherosclerotic stenosis using high-resolution MRI study--rationale and design

Brain and Behavior
Tanya N TuranTruman R Brown

Abstract

Intracranial atherosclerosis is a leading cause of stroke, but little is known about the composition of the intracranial atherosclerotic lesion and how intracranial plaque morphology is related to the risk of stroke. High-resolution magnetic resonance imaging (HR MRI) has been used in patients with extracranial carotid atherosclerosis as an in vivo tool to identify, with high-interrater agreement, histologically defined plaque components (i.e., intraplaque hemorrhage, fibrous cap, and lipid core), which have been shown to be predictors of recurrent stroke. With careful imaging the components of atherosclerotic plaque can be visualized in the intracranial arteries using HR MRI, but there are no reports of reproducibility or interrater reliability. The Characterization of intracranial atherosclerotic stenosis using high-resolution MRI (CHIASM) study is a single-center NIH-funded prospective observational study, to (1) demonstrate high -interrater agreement for identifying intracranial plaque components on HR MRI, (2) determine the frequency of these components in symptomatic versus asymptomatic plaques, and (3) estimate the 1-year rate of stroke in the territory of high-risk plaque components. CHIASM will recruit 90 patients with...Continue Reading

References

Jul 1, 1979·Stroke; a Journal of Cerebral Circulation·S SadoshimaK Tanaka
Jan 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·J OgataT Yamaguchi
Mar 15, 1993·The American Journal of Cardiology·J B HermillerC J Davidson
Jan 17, 2002·Journal of Magnetic Resonance Imaging : JMRI·Chun YuanThomas S Hatsukami
Jan 24, 2002·Circulation·Allen P BurkeRenu Virmani
Mar 26, 2003·Journal of Magnetic Resonance Imaging : JMRI·Lee M MitsumoriChun Yuan
Mar 27, 2003·Neuroepidemiology·UNKNOWN Warfarin-Aspirin Symptomatic Intracranial Disease (WASID) Trial Investigators
Apr 3, 2004·Stroke; a Journal of Cerebral Circulation·Baocheng ChuChun Yuan
Jul 6, 2004·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·R A TrivediJ H Gillard
Nov 6, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·T SaamC Yuan
Mar 1, 2005·Journal of the American College of Cardiology·Atsushi YonemuraFumitaka Ohsuzu
Apr 1, 2005·The New England Journal of Medicine·Marc I ChimowitzUNKNOWN Warfarin-Aspirin Symptomatic Intracranial Disease Trial Investigators
Mar 2, 2006·Current Cardiology Reports·Jesse Weinberger
Mar 24, 2007·Stroke; a Journal of Cerebral Circulation·Nishath AltafDorothee P Auer
Jan 12, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·J M U-King-ImJ H Gillard
Feb 2, 2008·Stroke; a Journal of Cerebral Circulation·Fadi NahabUNKNOWN WASID Study Group
Jun 7, 2008·Stroke; a Journal of Cerebral Circulation·Philip B GorelickDilip K Pandey
Aug 19, 2008·International Journal of Stroke : Official Journal of the International Stroke Society·Lawrence K S Wong
Jun 27, 2009·Journal of Magnetic Resonance Imaging : JMRI·William S KerwinXueqiao Zhao
Feb 4, 2010·Journal of Vascular and Interventional Radiology : JVIR·Laura Findeiss
Jun 12, 2010·Stroke; a Journal of Cerebral Circulation·Isabelle F KleinPierre Amarenco
Dec 20, 2011·Circulation·Véronique L RogerUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jan 5, 2012·Circulation·Véronique L RogerUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Mar 1, 2012·Annals of Neurology·Wei-Hai XuLi-Ying Cui

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Citations

Mar 11, 2017·Journal of Neurointerventional Surgery·Ju-Yu ChuehTanya N Turan
Feb 6, 2017·Circulation Research·Chirantan Banerjee, Marc I Chimowitz
Jan 22, 2019·Stroke; a Journal of Cerebral Circulation·Ning MaXin Lou
Jan 17, 2020·Journal of Magnetic Resonance Imaging : JMRI·Jin LiXihai Zhao
Aug 14, 2020·The Cochrane Database of Systematic Reviews·Tao WangLiqun Jiao
Sep 29, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Cuiting ZhuXingquan Zhao
Jul 9, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Jie-Ji ZhaoZhuan Xu

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Software Mentioned

REDCap ( Research Electronic Data Capture )
MUSC
Linux

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