Characterization of intrathecal cerebrospinal fluid geometry and dynamics in cynomolgus monkeys (macaca fascicularis) by magnetic resonance imaging

PloS One
Mohammadreza KhaniBryn A Martin

Abstract

Recent advancements have been made toward understanding the diagnostic and therapeutic potential of cerebrospinal fluid (CSF) and related hydrodynamics. Increased understanding of CSF dynamics may lead to improved detection of central nervous system (CNS) diseases and optimized delivery of CSF based CNS therapeutics, with many proposed therapeutics hoping to successfully treat or cure debilitating neurological conditions. Before significant strides can be made toward the research and development of interventions designed for human use, additional research must be carried out with representative subjects such as non-human primates (NHP). This study presents a geometric and hydrodynamic characterization of CSF in eight cynomolgus monkeys (Macaca fascicularis) at baseline and two-week follow-up. Results showed that CSF flow along the entire spine was laminar with a Reynolds number ranging up to 80 and average Womersley number ranging from 4.1-7.7. Maximum CSF flow rate occurred ~25 mm caudal to the foramen magnum. Peak CSF flow rate ranged from 0.3-0.6 ml/s at the C3-C4 level. Geometric analysis indicated that average intrathecal CSF volume below the foramen magnum was 7.4 ml. The average surface area of the spinal cord and dura w...Continue Reading

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Citations

Jul 26, 2019·Journal of Biomechanical Engineering·Mohammadreza KhaniBryn A Martin
Jan 22, 2020·Fluids and Barriers of the CNS·Lucas R SassBryn A Martin
Sep 8, 2021·Regional Anesthesia and Pain Medicine·Chinar SanghviMichael J Jung

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Methods Mentioned

BETA
sedation

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Achieva
SAS
ANSYS ICEM
MATLAB
ITK
GTFLOW
ANSYS FLUENT
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