Characterization of iron oxide nanoparticles adsorbed with cisplatin for biomedical applications

Physics in Medicine and Biology
Melanie KetteringIngrid Hilger


The aim of this study was to characterize the behaviour of cisplatin adsorbed magnetic nanoparticles (cis-MNPs) for minimal invasive cancer treatments in preliminary in vitro investigations. Cisplatin was adsorbed to magnetic nanoparticles (MNPs) by simple incubation. For stability determinations, cis-MNPs were incubated in dH(2)O, phosphate-buffered saline (PBS) and fetal calf serum (FCS) at 4-121 degrees C up to 20 weeks. Hydrodynamic diameters were measured using laser diffraction. The extent of cisplatin linkage was determined by atomic absorption spectrometry. The magnetite core size was assessed by vibrating sample magnetometry and transmission electron microscopy. The specific loss power (SLP) was measured in an alternating magnetic field. Our results showed that a maximum of 10.3 +/- 1.6 (dH(2)O), 10 +/- 1.6 (PBS) and 13.4 +/- 2.2 (FCS) mg cisplatin g(-1) Fe could be adsorbed to MNPs. With hyperthermal (42 degrees C) or thermal ablative (60 degrees C) temperatures, used for therapeutic approaches, cisplatin did not desorb from cis-MNPs in dH(2)O during incubation times of 180 or 30 min, respectively. In PBS and FCS, cisplatin amounts adsorbed to MNPs decreased rapidly to approximately 50% and 25% at these temperatures. ...Continue Reading


Mar 1, 1989·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·G ToffoliM Boiocchi
Jan 9, 1998·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·A JordanR Felix
Jan 17, 2002·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·I HilgerW A Kaiser
Sep 28, 2002·Investigative Radiology·Ingrid HilgerWerner A Kaiser
Feb 13, 2003·Journal of the American Chemical Society·Ansil DyalRichard A Gross
Jun 24, 2003·Biological Chemistry·Christian PlankJoseph Rosenecker
Jul 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Devin DressmanBert Vogelstein
May 18, 2004·The Journal of Surgical Research·Edward H Livingston
Mar 25, 2005·Nature Reviews. Drug Discovery·Dong Wang, Stephen J Lippard
May 17, 2005·European Biophysics Journal : EBJ·Stefan Trapp, Richard W Horobin
Oct 20, 2005·Journal of Bioscience and Bioengineering·Akira ItoTakeshi Kobayashi
Oct 26, 2005·Radiology·Ingrid HilgerWerner Alois Kaiser
Jan 19, 2006·Current Opinion in Biotechnology·Jan Roelof van der Meer
Jan 31, 2006·IEE Proceedings. Nanobiotechnology·I HilgerW A Kaiser
Feb 1, 2006·European Biophysics Journal : EBJ·Christoph AlexiouFritz G Parak
Feb 25, 2006·Colloids and Surfaces. B, Biointerfaces·Peisheng XuYouqing Shen
Nov 23, 2006·Advanced Drug Delivery Reviews·Claire CorotMarc Port

❮ Previous
Next ❯


May 16, 2012·Pharmaceutical Research·Dhrumil UpadhyayWojciech Chrzanowski
Feb 9, 2010·Pediatric Research·Kevin M McCabe, Mark Hernandez
Oct 1, 2013·Nanomedicine·Madeline Torres-Lugo, Carlos Rinaldi
Sep 22, 2012·Nanomedicine·Ingrid Hilger, Werner A Kaiser
Feb 6, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Xiaopin DuanWenbin Lin
Sep 29, 2015·Biomedizinische Technik. Biomedical Engineering·Stefan Odenbach
Oct 23, 2013·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Alicia A PetrykP Jack Hoopes
Dec 22, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Raphael Cândido Apolinário PeixotoSônia Nair Báo
Sep 10, 2015·Biomedizinische Technik. Biomedical Engineering·Melanie KetteringIngrid Hilger
Sep 8, 2010·Advanced Materials·Brian P TimkoDaniel S Kohane
Jul 2, 2020·Advanced Drug Delivery Reviews·David C LutherVincent M Rotello
Jul 10, 2021·The Journal of Chemical Physics·Megan J ThompsonTina Düren
Feb 5, 2019·ACS Chemical Neuroscience·Ruby Gupta, Deepika Sharma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.