Characterization of isoforms of activin receptor-interacting protein 2 that augment activin signaling

The Journal of Endocrinology
Z-H LiuHiromu Sugino

Abstract

Activin type II receptors (ActRIIs) including ActRIIA and ActRIIB are serine/threonine kinase receptors that form complexes with type I receptors to transmit intracellular signaling of activins, nodal, myostatin and a subset of bone morphogenetic proteins. ActRIIs are unique among serine/threonine kinase receptors in that they associate with proteins having PSD-95, Discs large and ZO-1 (PDZ) domains. In our previous studies, we reported specific interactions of ActRIIs with two independent PDZ proteins named activin receptor-interacting proteins 1 and 2 (ARIP1 and ARIP2). Overexpression of both ARIP1 and ARIP2 reduce activin-induced transcription. Here, we report the isolation of two isoforms of ARIP2 named ARIP2b and 2c. ARIP2, ARIP2b and ARIP2c recognize COOH-terminal residues of ActRIIA that match a PDZ-binding consensus motif. ARIP2 and its isoforms have one PDZ domain in the NH2-terminal region, and interact with ActRIIA. Although PDZ domains containing GLGF motifs of ARIP2b and 2c are identical to that of ARIP2, their COOH-terminal sequences differ from that of ARIP2. Interestingly, unlike ARIP2, overexpression of ARIP2b or 2c did not affect ActRIIA internalization. ARIP2b/2c inhibit inhibitory actions of ARIP2 on activin...Continue Reading

Citations

Jun 23, 2009·Cell Communication and Signaling : CCS·Kunihiro TsuchidaKaoru Inokuchi
Mar 20, 2008·World Journal of Gastroenterology : WJG·Alev DeliMichael Grusch
Jul 11, 2013·World Journal of Gastroenterology : WJG·Dong-Hui WangXue-Ling Cui
Aug 2, 2012·Journal of Neuroendocrinology·H Y LiuZ-H Liu
Jun 16, 2009·General and Comparative Endocrinology·Hai-Yan LiuZhong-Hui Liu
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Sep 18, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Giuseppe CiancioloMario Cozzolino

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