Characterization of kidney damage using several renal biomarkers in dogs with naturally occurring heatstroke

The Veterinary Journal
G SegevY Bruchim

Abstract

Heatstroke is often associated with acute kidney injury (AKI). The objectives of this study were to characterize the kidney damage occurring in canine heatstroke using routine and novel biomarkers and to assess their diagnostic and prognostic performance. Thirty dogs with naturally occurring heatstroke were enrolled prospectively. Blood and urine specimens were collected at presentation, at 4 h post-presentation and every 12 h until discharge or death. The glomerular filtration rate (GFR) and electrolyte fractional excretion (FE) at 4 h post-presentation were also calculated, based on urinary clearances. AKI was further characterized by evaluating urine neutrophil gelatinase-associated lipocalin/creatinine ratio (UNGAL), urine retinol-binding protein/creatinine ratio (URBP), urine C-reactive protein/creatinine ratio (UCRP) and urine protein to creatinine ratio (UPC). These biomarkers were compared to those for 13 healthy dogs. Thirteen dogs (43%) died and 17 (57%) survived. Median serum creatinine concentration at presentation was 1.69 mg/dL (range, 0.5-4.7 mg/dL), while concurrent GFR was markedly decreased (median 0.60 mL/min/kg; range, 0.00-3.10 mL/min/kg). Median Na fractional excretion was 0.08 (range, 0.01-0.41) and was a...Continue Reading

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Citations

Jun 24, 2017·Cell Stress & Chaperones·Yaron BruchimMichal Horowitz
Dec 18, 2018·The Journal of Veterinary Medical Science·Adam Stern
Apr 23, 2019·The Journal of Small Animal Practice·F C BuserT Francey
Jun 20, 2019·The New England Journal of Medicine·Yoram Epstein, Ran Yanovich
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Aug 3, 2021·Experimental and Therapeutic Medicine·Yue LiLei Su
Nov 26, 2021·Frontiers in Veterinary Science·Fabiola de Oliveira Paes-LemeAdriane Costa Val

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