Characterization of large mumps outbreak among vaccinated Palestinian refugees.

Journal of Clinical Microbiology
Musa Y HindiyehElla Mendelson

Abstract

During a large mumps virus (MuV) outbreak which occurred in the Palestinian refugee camps of the West Bank, 68.1% (2,636/3,871) of the cases were vaccinated with one dose of trivalent measles, mumps, and rubella (MMR) vaccine. Attack rates by camp ranged from less than 1 case per 1,000 people in the population to 43/1,000 (overall, 11/1,000). The outbreak lasted from December 2003 to June 2005, with two peaks, one from April to May 2004 and the other from March to April 2005. To control the outbreak, a mass MMR vaccination campaign was conducted in May 2005. Evaluation of the immune status of cases (n=59) and healthy controls (n=51) revealed high levels of mumps immunoglobulin G (IgG) and a low MuV-specific IgM in clinical cases indicative of a booster immune response. This suggested a secondary rather than a primary infection due to the insufficient protection conferred by the single vaccine dose included in the vaccination program. This prediction was further confirmed by the low seroprevalence (68.6%) found in the healthy control group, which was below the threshold level required for MuV herd immunity. Mumps diagnosis was established mainly by reverse transcription-PCR in clinical samples obtained within 48 h from the onset...Continue Reading

References

Aug 1, 1991·The Journal of Pediatrics·B S HershC L Wood
Nov 1, 1973·The Tohoku Journal of Experimental Medicine·Y ChibaS Chiba
Jan 1, 1995·Journal of Medical Virology·J P GutA Kirn
Nov 5, 1998·Clinical and Diagnostic Laboratory Immunology·M NaritaT Togashi
Mar 4, 1999·Bulletin of the World Health Organization·A M GalazkaA Kraigher
Feb 5, 2002·Australian and New Zealand Journal of Public Health·M A RiddellH A Kelly
Jun 19, 2002·Scandinavian Journal of Infectious Diseases·Bo JohanssonClaes Orvell
Oct 1, 1958·Proceedings of the Society for Experimental Biology and Medicine·J P UTZJ A KASEL
Feb 26, 2004·Paediatric Respiratory Reviews·Pearay L Ogra
Mar 26, 2004·Journal of Medical Virology·Joo-Yeon LeeWoo-Joo Kim
Jul 13, 2004·Vaccine·Corinne VandermeulenKarel Hoppenbrouwers
Aug 11, 2004·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Shuji HatakeyamaSatoshi Kimura
Mar 1, 2006·Lancet·Iain P WhartonMichael E French
Apr 8, 2006·MMWR. Morbidity and Mortality Weekly Report·UNKNOWN Centers for Disease Control and Prevention (CDC)
Aug 4, 2006·Vaccine·Marie-Claude BonnetStanley A Plotkin
Mar 21, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Fiona ReidJeff Connell
Apr 12, 2008·The New England Journal of Medicine·Gustavo H DayanJane F Seward
Apr 19, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Philip M PolgreenMichael A Pentella
Apr 29, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·J A BogaS Melón

❮ Previous
Next ❯

Citations

Nov 11, 2011·Journal of Virology·Steven A RubinW Paul Duprex
Jul 26, 2013·Indian Journal of Medical Microbiology·M JeevanM Thangam
Mar 10, 2016·Vaccine·Sigrid GoumaRob S van Binnendijk
Sep 12, 2015·International Journal of Medical Microbiology : IJMM·Annette MankertzSabine Santibanez
Nov 27, 2014·Reviews in Medical Virology·Li JinKevin E Brown
Sep 26, 2015·Human Vaccines & Immunotherapeutics·Eugene LamMuireann Brennan
Jun 18, 2011·Journal of Medical Microbiology·Haijing ShiQihan Li
Jun 30, 2015·Indian Pediatrics·Vipin M VashishthaPravin J Mehta
Oct 11, 2011·Vaccine·Ewout B FanoyRobert S van Binnendijk
Oct 11, 2011·Vaccine·Sabine DittrichRobert van Binnendijk
Jun 14, 2016·Journal of Global Infectious Diseases·Jeevan MalaiyanThangam Menon
Feb 18, 2012·The Cochrane Database of Systematic Reviews·Vittorio DemicheliCarlo Di Pietrantonj
Apr 21, 2020·The Cochrane Database of Systematic Reviews·Carlo Di PietrantonjVittorio Demicheli
Jun 6, 2018·Virology Journal·Arnaud G L'HuillierTony Mazzulli
Jun 8, 2021·Expert Review of Vaccines·Florence KauffmannGiacomo Casabona
Nov 23, 2021·The Cochrane Database of Systematic Reviews·Carlo Di PietrantonjVittorio Demicheli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
M C BaasF J Bemelman
BMJ : British Medical Journal
Ravindra K GuptaEithne MacMahon
© 2021 Meta ULC. All rights reserved