Characterization of leukocyte subtypes in chicken inner ear sensory epithelia

The Journal of Comparative Neurology
Elizabeth K O'Halloran, E C Oesterle

Abstract

Human hearing and balance require intact inner ear sensory hair cells, which transduce mechanical stimuli into electrical signals that are transmitted to the brain. Loss of hair cells after birth in mammals is irreversible, whereas birds are able to regenerate hair cells after insult and demonstrate ongoing hair cell production in the vestibular epithelia. Leukocytes reside in undamaged sensory epithelia of the avian inner ear and increase in number after trauma, prior to the proliferation of hair cell progenitors. It has been hypothesized that leukocyte-produced growth factors or cytokines may be involved in triggering hair cell regeneration. Little is known about the specific leukocyte subtypes present in avian ear. Immunohistochemistry with a panel of monoclonal antibodies to chicken leukocytes was used to identify leukocyte subtypes in normal posthatch chicken ear sensory epithelia. The responsiveness of the leukocytes to aminoglycoside-induced damage was also observed. Based on immunocytochemical and morphological criteria, we quantified leukocyte subtypes in normal and drug-damaged auditory and vestibular sensory epithelia. Data indicate that lymphocytes (B and T cells) do not reside in normal or drug-damaged ear sensory ...Continue Reading

References

Sep 15, 1978·The Journal of Comparative Neurology·N Hirokawa
Oct 1, 1978·The American Journal of Anatomy·K Tanaka, C A Smith
Oct 1, 1992·Journal of Neuroscience Research·S GanterP J Gebicke-Härter
Oct 1, 1992·Journal of Neuroimmunology·F Russo-Marie
Jan 1, 1992·Brain Research. Brain Research Reviews·W E Thomas
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J M LahtiM D Cooper
Jan 1, 1992·Hearing Research·D F RobersonE W Rubel
Jan 1, 1991·Annual Review of Immunology·R M Steinman
May 1, 1991·Peptides·C R Plata-Salamán
Jan 31, 1991·Biochemical and Biophysical Research Communications·L SchalchT W Jungi
Feb 25, 1991·Neuroscience Letters·M ShimojoS Kohsaka
Nov 1, 1990·The American Journal of Medicine·L C Platanias, N J Vogelzang
Jul 1, 1986·The Journal of Experimental Medicine·C L ChenM D Cooper
Mar 1, 1986·The Journal of Investigative Dermatology·C A FosterA G Farr
Jan 1, 1989·Brain, Behavior and Evolution·J M Jørgensen, J T Christensen
Feb 1, 1989·European Journal of Immunology·E HoussaintO Vainio
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R K AssoianM B Sporn
Oct 1, 1988·The Laryngoscope·M Takahashi, J P Harris
Nov 1, 1988·The Journal of Clinical Investigation·W N RomR G Crysal
Feb 1, 1988·The Journal of Experimental Medicine·J T SowderM D Cooper
Jun 24, 1988·Science·J T Corwin, D A Cotanche
Aug 15, 1985·The Journal of Comparative Neurology·M Lavigne-RebillardR Pujol
Jan 1, 1970·Archiv für klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde·U Rosenhall
Apr 1, 1971·Journal of Ultrastructure Research·T Takasaka, C A Smith
Jun 1, 1969·Acta Oto-laryngologica·V JahnkeJ Wersäll
Jan 1, 1971·Archiv für klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde·U Rosenhall
Jan 1, 1984·Developmental and Comparative Immunology·K HálaD L Ewert
Dec 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J WhartonA G Pearse
May 8, 1995·The Journal of Comparative Neurology·L LiA Forge
Feb 3, 1995·Science·E W RubelD W Roberson

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Citations

Sep 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jonathan E BirdJonathan E Gale
Sep 8, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Hainan LangBradley A Schulte
Jul 20, 2018·Journal of Anatomy·David DoraNandor Nagy
May 15, 2007·Journal of Neuroscience Research·Sabine LadrechMarc Lenoir
Jun 29, 2005·The Journal of Comparative Neurology·Keiko HiroseRichard Ransohoff
Sep 6, 2018·Cold Spring Harbor Perspectives in Medicine·Mark E Warchol
Sep 8, 2017·Frontiers in Cellular Neuroscience·Shimon P Francis, Lisa L Cunningham

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