Characterization of Lipoprotein Composition and Function in Pediatric Psoriasis Reveals a More Atherogenic Profile

The Journal of Investigative Dermatology
Wynnis L TomNehal N Mehta

Abstract

Psoriasis is associated with increased cardiovascular disease in adults, but the risk profile of children with psoriasis remains to be fully characterized. We measured lipoprotein composition and function in 44 patients with pediatric psoriasis and 44 age- and sex-matched healthy controls, using nuclear magnetic resonance spectroscopy and a validated ex vivo assay of high-density lipoprotein cholesterol efflux capacity. The mean age of the patients was 13 years and the population was ethnically diverse. Children with psoriasis had higher waist-to-hip ratios (0.85 vs. 0.80; P < 0.002) and insulin resistance measures (log-transformed homeostasis model assessment of insulin resistance 0.65 vs. 0.41; P = 0.07). Despite comparable traditional lipid values, having psoriasis was associated with higher apolipoprotein B concentrations (72.4 vs. 64.6; P = 0.02), decreased large high-density lipoprotein particles (5.3 vs. 6.7; P < 0.01), and reduced cholesterol efflux capacity after adjusting for age, sex, fasting glucose, homeostasis model assessment of insulin resistance, systolic blood pressure, body mass index, apolipoprotein A-1, and high-density lipoprotein cholesterol concentration (β -0.22; P = 0.02). Patients with pediatric psori...Continue Reading

Citations

Sep 16, 2017·Journal of Biomedical Science·Maria Joao Paiva-Lopes, José Delgado Alves
Apr 30, 2017·Pediatrics International : Official Journal of the Japan Pediatric Society·Awatef KelatiFatima Z Mernissi
Aug 23, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Lisa EisertMichael Sticherling
Jan 29, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·C BlegvadL Skov
Jan 10, 2018·Pediatric Dermatology·Lawrence F EichenfieldKelly M Cordoro
Oct 27, 2017·International Journal of Molecular Sciences·Stephen Chu-Sung Hu, Cheng-Che E Lan
Aug 23, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Lisa EisertMichael Sticherling
Jun 3, 2021·Biomedicines·Athina Trakaki, Gunther Marsche
May 22, 2021·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·Bianca Y KangIsrael D Andrews

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Methods Mentioned

BETA
nuclear magnetic resonance
NMR

Software Mentioned

STATA

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