PMID: 6967460Jan 15, 1980Paper

Characterization of lymphocyte subsets in spontaneous mouse mammary tumors and host lymphoid organs

International Journal of Cancer. Journal International Du Cancer
V SanterP K Lala

Abstract

The subsets of small lymphocytes (surface Igm-positive or B, Thy-I-positive or T and "double-negative" or null) appearing within spontaneous mammary tumors of C3H retired breeder female mice and in various lymphoid organs of the host at different stages of tumor development were characterized directly using a radioautographic method. Tumor-bearing mice showed early transient splenomegaly and progressive atrophy of the thymus. The proportion of T small lymphocytes increased with tumor age within the tumor and in the spleen, blood and thymus; then, except in the spleen, these proportions declined again by 8 weeks of tumor growth. The incidence of B small lymphocytes showed no change in the tumor or thymus; there was an increase in the blood after 3 weeks, and a small decrease in the spleen after 7 weeks. At all the sites examined, the proportion of null small lymphocytes declined from an initial high level observed in the elderly tumor-free control mice, and then recovered to control levels after 7 weeks. The absolute numbers of T and null cells in the spleen changed in parallel to their proportions, while splenic B-cell numbers increased at 1-3 weeks. In the thymus the absolute numbers of all subsets decreased, with a late recov...Continue Reading

References

Jan 15, 1976·International Journal of Cancer. Journal International Du Cancer·M RanI P Witz
Jul 1, 1977·Journal of the National Cancer Institute·P K Lala, L Kaizer
Jan 15, 1978·International Journal of Cancer. Journal International Du Cancer·G Y Gillespie, S W Russell
Jun 1, 1978·Journal of the National Cancer Institute·J H KornF L Ritter
Jan 1, 1979·Advances in Experimental Medicine and Biology·P K LalaV Santer
Mar 15, 1978·International Journal of Cancer. Journal International Du Cancer·N Schaaf-Lafontaine
Jun 1, 1978·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R B WhitneyJ G Levy
May 1, 1977·Cell and Tissue Kinetics·L Kaizer, P K Lala
Sep 15, 1977·International Journal of Cancer. Journal International Du Cancer·J S Haskill
Nov 15, 1975·International Journal of Cancer. Journal International Du Cancer·J S HaskillL Radov
Dec 15, 1975·International Journal of Cancer. Journal International Du Cancer·M DorizziR S Epstein
Sep 15, 1976·International Journal of Cancer. Journal International Du Cancer·S W RussellC G Cochrane
Jun 15, 1975·International Journal of Cancer. Journal International Du Cancer·R S KerbelE V Elliott
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Oct 1, 1963·The Biochemical Journal·F C GREENWOODJ S GLOVER
Dec 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·P K Lala, H M Patt

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Citations

Nov 14, 1997·International Journal of Cancer. Journal International Du Cancer·P K LalaA Orucevic
Sep 1, 1985·The Journal of Pathology·C F KuperG Wolterink
Jan 1, 1989·Digestive Diseases and Sciences·M VentrucciL Barbara
Sep 1, 1985·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology·T BrøynJ L Svennevig

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