PMID: 9182853Jan 1, 1997Paper

Characterization of mechanisms of interleukin-6 gene repression by estrogen receptor

The Journal of Steroid Biochemistry and Molecular Biology
S KurebayashiT Kishimoto

Abstract

Estrogens are the most effective agents available for preventing osteoporosis, and their principal role in bone metabolism is the inhibition of interleukin-6 (IL-6) production in osteoblasts and bone marrow stromal cells. We examined the mechanism of inhibitory effect of estrogens on the 190 bp proximal promoter of the IL-6 gene. Promoter activity induced by transfection of both NF-kappaB p65 subunit and NF-IL6 was decreased by 45% by estradiol (E2)-estrogen receptor (ER) complexes. The inhibitory effect of E2 was also observed on a mutant IL-6 promoter in which the NF-IL6 binding site was disrupted. E2 repressed the wild-type promoter activity induced by NF-kappaB p65 subunit alone, but had no effect on that induced by NF-IL6 alone. These findings suggested that estrogens inhibit IL-6 production by interfering with the function of NF-kappaB rather than that of NF-IL6. The ER mutant, HE19, which does not contain the A/B domain, repressed the induction by NF-kappaB to the same extent as wild-type ER HE0, whereas the effect of C-terminal deletion mutant, HE21, was only marginal. The antiestrogen, 4-hydroxytamoxifen (OHT), had no effect on IL-6 promoter activity, suggesting that E2-induced conformational change of the hormone bind...Continue Reading

References

Mar 26, 1992·The New England Journal of Medicine·R R LoveD L DeMets
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Citations

Mar 14, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Rocio SanchezSylvie Mader
Oct 24, 2003·Neuropharmacology·H JiangS L Ho
Jan 7, 1999·The Journal of Steroid Biochemistry and Molecular Biology·G CerilloM Needham
Jun 10, 2000·Molecular and Cellular Biology·D G MonroeM M Sanders
Jun 24, 2004·Journal of Periodontology·Mark A ReynoldsEugene D Albrecht
Aug 16, 2011·Molecular and Cellular Endocrinology·Ann E Drummond, Peter J Fuller
May 20, 2009·International Journal of Cancer. Journal International Du Cancer·Martha L SlatteryWade Samowitz
May 3, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Moisés García-ArencibiaConsuelo Calle
Nov 17, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Michael M WangTongyun Liu
Aug 2, 2005·Biochemical and Biophysical Research Communications·Jason MatthewsJan-Ake Gustafsson
Nov 22, 2011·Expert Opinion on Therapeutic Patents·Jae-Hwan KwakHeesoon Lee
Jun 1, 2006·Expert Opinion on Therapeutic Patents·Irmgard Merfort
Nov 1, 2018·Cellular and Molecular Life Sciences : CMLS·Saeedeh Tajalli-NezhadAbolfazl Azami Tameh
Mar 1, 2007·Advances in Physiology Education·Margaret E Wierman
Jul 21, 2007·Endocrine Reviews·Rainer H Straub
Feb 15, 2002·Endocrine Reviews·Johannes PfeilschifterHelmut Schatz
Jun 20, 2002·Endocrinology·Mark J EvansChristopher C Chadwick

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