PMID: 2428758Oct 15, 1986Paper

Characterization of melanoma-associated surface antigens involved in the adhesion and motility of human melanoma cells

International Journal of Cancer. Journal International Du Cancer
J E de VriesC G Figdor

Abstract

The functional properties of the melanoma-associated antigens detected by monoclonal antibodies (MAbs) AMF-6 and AMF-7 were investigated. These MAbs were selected previously because of their capacity to block the anti-melanoma reactivity of cytotoxic T-lymphocyte clones AMF-6 and AMF-7 detect a melanoma-associated proteoglycan (MW greater than 450-250 kDa) and a molecular complex, which under reducing conditions consists of 4 compounds of 120, 95, 29 and 25 kDa respectively. AMF-6 reacted strongly with all 30 cultured melanomas and all 41 melanomas in frozen tissue sections. Significant cross-reactivity was only observed with nevi and perineurium, whereas normal skin melanocytes were negative. AMF-7 reacted with all 25 cultured melanomas and all 34 melanomas in frozen sections. AMF-7 cross-reacted with a proportion of nevi and endothelial cells from small vessels. The antigen detected by AMF-6 and AMF-7 could not be modulated by retinoic acid or recombinant gamma-IFN, which induced or enhanced the expression of HLA-DR, HLA-DQ and Class-I MHC antigens. In addition, the antigens were not readily modulated when cells were incubated in excess amounts of AMF-6 and AMF-7. Interestingly, the antigen detected by AMF-7 was strongly asso...Continue Reading

References

Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·C R BirdwellG L Nicolson
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R H Kramer, G L Nicolson
May 15, 1972·International Journal of Cancer. Journal International Du Cancer·J P FaucaultC Lecacheux
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·T F Bumol, R A Reisfeld
Jul 1, 1984·The Journal of Experimental Medicine·H YsselJ E de Vries
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·I S Trowbridge, M B Omary
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·V P TerranovaL A Liotta
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·H P Vollmers, W Birchmeier
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D A ChereshR A Reisfeld
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·H P Vollmers, W Birchmeier
Apr 1, 1984·European Journal of Immunology·H SpitsJ E De Vries
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·K F MitchellH Koprowski
Jan 10, 1980·Nature·G Poste, I J Fidler
Feb 15, 1982·International Journal of Cancer. Journal International Du Cancer·G HaemmerliP Sträuli
Nov 15, 1980·International Journal of Cancer. Journal International Du Cancer·R H KramerG L Nicolson

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Citations

Mar 23, 2000·The Journal of Pathology·C B MeijeP K Das
Jan 1, 1996·Biopolymers·J B McCarthyJ Iida
Dec 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M A Horton, J Davies
Mar 5, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·D SuesskindS Henke-Fahle
Dec 24, 1997·Clinics in Dermatology·I C Le Poole, P K Das
Jun 1, 1991·The Journal of Experimental Medicine·M GiuntaG Corte
Oct 1, 1993·Hybridoma·S Ferrone
Aug 16, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zeyana RiveraMichele Carbone
Jan 1, 1989·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·P J RingensA W van der Kamp
May 1, 1991·Clinical & Experimental Metastasis·G N Van MuijenD J Ruiter
Jan 1, 1997·In Vitro Cellular & Developmental Biology. Animal·I C Le PooleP K Das
Oct 14, 2004·The Journal of Cell Biology·DeannaLee M BeauvaisAlan C Rapraeger
Jun 1, 1987·Current Eye Research·J P van der PolD J Ruiter
Jul 30, 1991·International Journal of Cancer. Journal International Du Cancer·S CarrelE B Bröcker
Apr 24, 2009·Human Pathology·Clifton B MeijeJoost J Van den Oord
Mar 11, 2004·The Journal of Investigative Dermatology·Lucy GhaliIrene M Leigh
Dec 4, 2004·International Journal of Cancer. Journal International Du Cancer·Christine HafnerHubert Pehamberger
Jan 29, 2009·International Journal of Cancer. Journal International Du Cancer·Cornelia ErfurtErwin S Schultz
Sep 15, 1989·International Journal of Cancer. Journal International Du Cancer·M MaioS Ferrone
Dec 2, 1998·Molecular Carcinogenesis·E R Sauter, M Herlyn
Mar 11, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jianhu ZhangMarc D Basson
Feb 21, 1997·The Journal of Biological Chemistry·K SuehiroE F Plow
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cornelia ErfurtErwin S Schultz
Dec 15, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Elisa TamburiniRoberto Perris
Jun 4, 2021·Thyroid : Official Journal of the American Thyroid Association·Caitlin E EganIrene M Min
Jun 1, 1993·The Journal of Investigative Dermatology·I C Le PooleP K Das

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