Characterization of mesenchymal stem cells from human vocal fold fibroblasts.

The Laryngoscope
Summer E HansonSusan L Thibeault

Abstract

Mesenchymal stem cells (MSCs) originally isolated from bone marrow (BM), are fibroblast-looking cells that are now assumed to be present in the stromal component of many tissues. MSCs are characterized by a certain set of criteria, including their growth culture characteristics, a combination of cell surface markers, and the ability to differentiate along multiple mesenchymal tissue lineages. We hypothesized that human vocal fold fibroblasts (hVFF) isolated from the lamina propria meet the criteria established to define MSCs and are functionally similar to MSCs derived from BM and adipose tissue. In vitro study. hVFF were previously derived from human vocal fold tissues. MSCs were derived from adipose tissue (AT), and BM of healthy donors based on their attachment to culture dishes and their morphology and expanded in culture. Cells were analyzed for standard cell surface markers identified on BM-derived MSCs and the ability to differentiate into cells of mesenchymal lineage (i.e., fat, bone, and cartilage). We investigated the immunophenotype of these cells before and after interferon-gamma (INF-gamma) stimulation. hVFF displayed cell surface markers and multipotent differentiation capacity characteristic of MSCs. Furthermore,...Continue Reading

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Citations

Jun 26, 2013·Annals of Biomedical Engineering·Jeffrey C Wolchok, Patrick A Tresco
Jan 11, 2012·Journal of Speech, Language, and Hearing Research : JSLHR·Rebecca S BartlettSusan L Thibeault
Dec 15, 2010·Stem Cells and Development·Kersti Jääger, Toomas Neuman
Sep 16, 2010·Current Opinion in Otolaryngology & Head and Neck Surgery·Jennifer L Long
Jan 28, 2014·Stem Cell Research & Therapy·Kyu-Sup ChoJayakar V Nayak
Jan 25, 2014·Tissue Engineering. Part a·Zhixiang TongXinqiao Jia
Feb 19, 2013·Journal of Tissue Engineering and Regenerative Medicine·Summer E HansonPeiman Hematti
Feb 5, 2016·The Laryngoscope·Yoshitaka KawaiShigeru Hirano
Dec 4, 2015·Advanced Healthcare Materials·Linqing LiKristi L Kiick
Jan 18, 2016·The Laryngoscope·Jonathan M FishmanMartin A Birchall
Dec 12, 2012·Journal of Tissue Engineering and Regenerative Medicine·Noor Hayaty Abu KasimZeti Adura Che Ab Aziz
Jul 17, 2012·Journal of Voice : Official Journal of the Voice Foundation·Markus GugatschkaShigeru Hirano
Nov 20, 2015·Science Translational Medicine·Changying LingNathan V Welham
May 9, 2013·Journal of Tissue Engineering and Regenerative Medicine·Xia Chen, Susan L Thibeault
Apr 9, 2013·Journal of Biomedical Materials Research. Part a·Suzanne N KingSusan L Thibeault
Oct 12, 2013·The Laryngoscope·Lucio Díaz-FloresDaniel López-Campos
Mar 20, 2013·Biomatter·Joel Gaston, Susan L Thibeault
Jul 15, 2016·Oxidative Medicine and Cellular Longevity·Ryan A Denu, Peiman Hematti
Apr 8, 2017·The Annals of Otology, Rhinology, and Laryngology·Suzanne N KingSusan L Thibeault
Mar 7, 2014·The Annals of Otology, Rhinology, and Laryngology·Mitsuyoshi ImaizumiSusan L Thibeault
Jan 25, 2013·The Annals of Otology, Rhinology, and Laryngology·Kiminori SatoTadashi Nakashima
May 1, 2020·BMJ : British Medical Journal·Michael J McPhailDavid G Lott
Jul 19, 2017·Oxidative Medicine and Cellular Longevity·Ryan A Denu
Jul 14, 2020·The Laryngoscope·Chenwei DuanM Preeti Sivasankar
Sep 16, 2020·International Journal of Molecular Sciences·Ho-Ryun WonBon Seok Koo
Oct 18, 2020·The Laryngoscope·Alicia Reyes ValenzuelaLuc Mongeau
Nov 3, 2020·Laryngoscope Investigative Otolaryngology·Kiminori SatoHirohito Umeno
Mar 8, 2021·Free Radical Biology & Medicine·Ryan A Denu, Peiman Hematti
Apr 17, 2021·Free Radical Biology & Medicine·Egidijus ŠimoliūnasDaiva Baltriukienė
Feb 24, 2011·Current Opinion in Otolaryngology & Head and Neck Surgery

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