Characterization of middle cerebral artery occlusion infarct development in the rat using fast nuclear magnetic resonance proton spectroscopic imaging and diffusion-weighted imaging

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
D G NorrisB Schmitz

Abstract

A nuclear magnetic resonance study of the middle cerebral artery occlusion in the rat is presented. Experiments were performed on seven animals before and after occlusion, which occurred in situ. The emphasis in this study was on evaluating rapid proton spectroscopic imaging. Data were acquired with experimental durations of between 4 and 15 minutes for a 32 by 32 spatial matrix, with 64 spectroscopic data points per spatial element. The spectroscopic data were interleaved with diffusion-weighted nuclear magnetic resonance water images of the same slice. The study was terminated at about 6 hours after occlusion. The brains were then frozen in liquid nitrogen for biochemical imaging. The results showed that the signal from N-acetyl aspartate decreased and that of lactate increased within the infarcted region. The temporal course of these intensity changes varied between animals. Nineteen cortical spreading depressions (CSD) were observed by electrophysiologic monitoring during the experiments. Of these, 11 could be unambiguously detected in the lactate images, and a further 3 were on the threshold of detectability. As only a single slice could be examined, it is possible that the centers of depression for the remaining 6 CSD wer...Continue Reading

References

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Citations

Jun 17, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H M Gach, I J Lowe
May 20, 2006·Cellular and Molecular Neurobiology·Konstantin-Alexander Hossmann
Feb 13, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xiaopeng ZongTao Jin
Apr 25, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·O AbeY Sasaki
Nov 18, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ralph WeberMathias Hoehn
Nov 7, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W Dreher, D Leibfritz
Dec 18, 2001·Journal of Magnetic Resonance Imaging : JMRI·M HoehnB van der Sanden
May 7, 2008·Expert Review of Neurotherapeutics·Justin M SmithChristopher L-H Huang
Dec 23, 2004·Nihon Hoshasen Gijutsu Gakkai zasshi·Jun Hatazawa

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Methods Mentioned

BETA
nuclear
imaging techniques
NMR
nuclear magnetic resonance

Software Mentioned

FLARE

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