Characterization of midface maxillary membranous bone formation during distraction osteogenesis

Plastic and Reconstructive Surgery
Adi RachmielDina Lewinson

Abstract

The purpose of the study was to follow the early events in bone formation and neovascularization during maxillary distraction and after the consolidation period and to define the characterization of the new bone in the distracted area. Maxillary osteotomy was performed in seven sheep. In five animals, an external distraction device was used for maxillary lengthening of 20 mm at a rate of 1 mm/day for 20 days. Another two animals served as controls without distraction. Sequential biopsies were performed. The methods used for analysis were histologic, immunohistochemical, and ultrastructural by transmission electron microscopy. During the 5 days of latency, a fibrin clot was formed that after 5 days of distraction was replaced by granulation tissue, proliferating mesenchyme-like cells, and capillaries. After 10 days of distraction, the regenerated tissue could be divided into three main zones and two transitional areas: a central zone occupied by many polygonal mesenchyme-like cells and spindle-shaped cells that proliferated intensively; two paracentral zones on both sides of the central zone in which many cells showed morphologic signs of apoptosis leading to a decreased number of fibroblast-like cells embedded in wavy collagen ...Continue Reading

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Citations

Aug 2, 2005·International Journal of Oral and Maxillofacial Surgery·A RachmielM Peled
Feb 14, 2013·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Adi RachmielDror Aizenbud
Dec 31, 2003·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Lim K Cheung, Qian Zhang
Jun 24, 2004·The Journal of Craniofacial Surgery·Franz-Josef KramerHannes Schierle
Jul 16, 2004·Plastic and Reconstructive Surgery·Jules A FeledyLarry Hollier
Jun 29, 2004·Plastic and Reconstructive Surgery·Jack C. YuJohn W. Polley
Mar 14, 2013·Annals of Maxillofacial Surgery·Adi RachmielDror Aizenbud
Mar 17, 2016·Annals of Maxillofacial Surgery·Adi Rachmiel, Dekel Shilo
Apr 21, 2012·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Maria E PapadakiMaria J Troulis
Jan 26, 2010·International Journal of Oral and Maxillofacial Surgery·W B KretschmerK Dietz
Aug 23, 2008·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Takahiro KannoYoshihiko Furuki
Mar 21, 2007·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Adi Rachmiel
Jul 4, 2009·Veterinary Surgery : VS·Pilar LafuenteCristina Manzanares
Mar 4, 2006·International Journal of Oral and Maxillofacial Surgery·K YamauchiT Takahashi
Nov 22, 2005·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Zvi LasterOle T Jensen
Mar 3, 2015·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Ji Hyun KimIn Young Park
Aug 19, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Dina LewinsonYaron Rabinovich
Jun 15, 2006·Plastic and Reconstructive Surgery·Adi RachmielMicha Peled
Jan 27, 2007·Plastic and Reconstructive Surgery·John N JensenMuhittin Eski
Oct 8, 2014·Plastic and Reconstructive Surgery. Global Open·Adi Rachmiel, Yoav Leiser
Nov 27, 2014·Plastic and Reconstructive Surgery. Global Open·Adi RachmielDror Aizenbud
Oct 1, 2019·The Journal of Craniofacial Surgery·Pandurangan Harikrishnan
Jan 26, 2005·Orthodontics & Craniofacial Research·Z J LiuG J King

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