PMID: 16629182Apr 25, 2006Paper

Characterization of mitochondrial iron uptake in HepG2 cells

Biological Research
Dora Inés MazariegosMarco Tulio Núñez

Abstract

There is increasing evidence that accumulation of redox-active iron in mitochondria leads to oxidative damage and contributes to various neurodegenerative diseases, such as Friedreich's ataxia and Parkinsons disease. In this work, we examined the existence of regulatory mechanisms for mitochondrial iron uptake and storage. To that end, we used rhodamine B-[(1,10-phenanthrolin-5-yl)amino carbonyl] benzyl ester, a new fluorescent iron-sensitive probe that is targeted specifically to the mitochondrion. We found that extracellular iron was incorporated readily into mitochondria in an apparently saturable process. Moreover, the rate of iron incorporation responded to the Fe status of the cell, an indication that the mitochondrion actively regulates its iron content.

Citations

Feb 11, 2015·Mitochondrion·Natalia P MenaMarco T Núñez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Related Papers

Oxidative Medicine and Cellular Longevity
Liliana Batista-NascimentoClaudina Rodrigues-Pousada
European Journal of Clinical Investigation
B SturmB Scheiber-Mojdehkar
© 2022 Meta ULC. All rights reserved