PMID: 6814493Oct 14, 1982Paper

Characterization of monohydroxylated lipoxygenase metabolites of arachidonic and linoleic acid in rabbit peritoneal tissue

Biochimica Et Biophysica Acta
M ClaeysD H Nugteren

Abstract

Rabbit peritoneal tissue contains a lipoxygenase which converts arachidonic acid preferentially into 15-hydroxy-5,8,11,13-eicosatetraenoic acid. Stereochemical analysis of the menthyloxycarbonyl derivative of this metabolite by means of a high-pressure liquid chromatography method, involving the use of a Ag+ -loaded cation-exchange column, indicated that it has mainly the 15-Ls-hydroxy configuration. The biosynthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid could be confirmed during examination of the monohydroxy acids obtained without addition of fatty acids, thus formed from endogenously released substrate. However, the 9-and 13-hydroxy derivatives of linoleic acid were also formed and in quantities exceeding those of 15-hydroxy-5,8,11,13-eicosatetraenoic acid.

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Citations

Aug 1, 1983·Agents and Actions·H Bult, A G Herman
Dec 1, 1987·Lipids·D L Smith, A L Willis
Jan 1, 1987·The International Journal of Biochemistry·E MalleG M Kostner
Sep 1, 1983·Prostaglandins·R D CampM W Greaves
Jul 1, 1983·The Journal of Clinical Investigation·Z MaromM Kaliner
Sep 21, 2005·Biochemical and Biophysical Research Communications·Shozo YamamotoNatsuo Ueda
Jan 1, 1995·Rapid Communications in Mass Spectrometry : RCM·G BioqueE Gelpí
Jan 12, 2021·Eating and Weight Disorders : EWD·S G SukkarD Cottalasso
Apr 1, 1994·The American Journal of Physiology·L L StollA A Spector
Sep 15, 1995·Journal of Chromatography. B, Biomedical Applications·G DobsonB Nikolova-Damyanova
Nov 15, 1985·Biochemical Pharmacology·M StüningW König
Sep 1, 1983·Biochemical Pharmacology·H Bult, A G Herman
Oct 23, 1985·Biochimica Et Biophysica Acta·M ClaeysD H Nugteren
Sep 18, 1990·Biochimica Et Biophysica Acta·C HadjiagapiouH Sprecher
Sep 25, 1987·Biochimica Et Biophysica Acta·P WalstraJ F Vliegenthart
Jan 1, 1987·Progress in Lipid Research·W S Powell, C D Funk

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