Characterization of motor skill and instrumental learning time scales in a skilled reaching task in rat

Behavioural Brain Research
Manuel M BuitragoAndreas R Luft

Abstract

Successful motor skill learning requires repetitive training interrupted by rest periods. In humans, improvement occurs within and between training sessions reflecting fast and slow components of motor learning [Karni A, Meyer G, Rey-Hipolito C, Jezzard P, Adams MM, Turner R, et al. The acquisition of skilled motor performance: fast and slow experience-driven changes in primary motor cortex. Proc Natl Acad Sci USA 1998;95:861-8]. Here, these components are characterized in male and female rats using a model of skilled forelimb reaching and are compared to time scales of instrumental learning. Twenty female and 14 male adult Long-Evans rats were pre-trained to operate a motorized door (via a sensor in the opposite cage wall) to access a food pellet by tongue. Latencies between pellet removal and door opening were recorded as measures of instrumental learning. After criterion performance was achieved, skilled forelimb reaching was requested by increasing the pellet-window distance to 1.5cm. Reaching success was recorded per trial. Mean latencies decreased exponentially over sessions and no improvement within-session was found. Skill learning over eight training sessions followed an exponential course in females and a sigmoid cour...Continue Reading

References

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Citations

Mar 28, 2007·Experimental Brain Research·Maximilian Schubring-GieseAndreas R Luft
Oct 14, 2009·Experimental Brain Research·Tobias WächterAndreas R Luft
Sep 18, 2009·PloS One·Katiuska Molina-LunaAndreas R Luft
May 3, 2013·PloS One·Vincent C K CheungKi A Goosens
Sep 29, 2011·Neural Plasticity·Joseph Thachil Francis, Weiguo Song
Sep 10, 2014·Experimental Brain Research·Jean-Jacques Orban de Xivry, Reza Shadmehr
Nov 28, 2012·Journal of Neuroscience Methods·Seth A HaysRobert L Rennaker
Aug 31, 2010·Journal of Neuroscience Methods·Joana M Marques, I Anna S Olsson
Mar 15, 2016·Frontiers in Human Neuroscience·Mona Sharon Julius, Esther Adi-Japha
Dec 21, 2006·Journal of Neuroscience Methods·Katiuska Molina-LunaAndreas R Luft
Jan 22, 2013·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Bogdan C VigaruRoger Gassert
Aug 1, 2014·Human Brain Mapping·Janne M HamannLeonardo G Cohen
Dec 29, 2011·Neurobiology of Learning and Memory·Amanda A DiepRobert F Berman
Mar 11, 2008·NeuroImage·Katiuska Molina-LunaAndreas R Luft
Dec 3, 2014·Behavioural Brain Research·O LambercyJ A Hosp
Jan 29, 2013·Journal of Neuroscience Methods·Seth A HaysRobert L Rennaker
Nov 15, 2011·Neuron·Eran Dayan, Leonardo G Cohen
Oct 28, 2015·PloS One·Andrew M SloanSeth A Hays
May 6, 2015·PloS One·Mengia-Seraina Rioult-PedottiAndreas Rüdiger Luft
Nov 5, 2016·Neurobiology of Learning and Memory·B HertlerJ A Hosp
Jun 18, 2016·PloS One·Maximilian Schubring-GieseJonas Aurel Hosp
Jan 14, 2018·Scientific Reports·Susan LeemburgAndreas Luft
Dec 24, 2018·Human Molecular Genetics·Jana SchmidtThorsten Schmidt
Oct 20, 2010·Somatosensory & Motor Research·Cornelius SchwarzChristian Waiblinger
Apr 11, 2012·The European Journal of Neuroscience·Amir Dezfouli, Bernard W Balleine
Mar 25, 2020·Sensors·Pieter Van den BergheDirk De Clercq
Dec 28, 2017·PloS One·Benjamin HertlerAndreas Rüdiger Luft
Jun 14, 2019·Neurorehabilitation and Neural Repair·Anil SindhurakarJason B Carmel
Nov 25, 2014·The Journal of Biological Chemistry·Hui-Yuan WuJames I Morgan
Nov 14, 2020·Neurobiology of Learning and Memory·Morgan E StevensonRodney A Swain
Aug 19, 2021·Journal of Neural Engineering·S BowlesC G Welle

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