PMID: 109484Jun 1, 1979

Characterization of mouse allergens

The Journal of Allergy and Clinical Immunology
R P Siraganian, A L Sandberg

Abstract

The major allergens present in mouse skin, serum, and urine have been identified. Skin extracts, serum, and urine were chromatographed, and the activities of the fractions were monitored by histamine release from the leukocytes of individuals sensitive to mice. Fractionation of skin extracts revealed two major allergens. The large allergen has a molecular weight of approximately 67,000 daltons and by biochemical and immunochemical criteria appears to be identical to mouse albumin. The smaller molecular weight allergen is approximately 17,000 daltons. The same two allergens are also found in mouse serum and mouse urine. Histamine release by leukocytes of individuals allergic to mice demonstrated that some individuals react predominantly to the large allergen, some to the small allergen, and one group of patients reacts to both allergens.

Citations

Aug 8, 2002·Current Allergy and Asthma Reports·Wanda Phipatanakul
Sep 1, 1980·Molecular Immunology·M J Schumacher
Jan 1, 1981·Molecular Immunology·U WahnR P Siraganian
Nov 4, 2000·Biochimica Et Biophysica Acta·R MäntyjärviT Virtanen
Jun 26, 2001·Allergy·S GordonA J Newman Taylor
Dec 21, 2000·ILAR Journal·R A Wood
Dec 11, 2002·ILAR Journal·R K Bush, Gregg M Stave
Jan 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J A Price, J L Longbottom
Jan 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C Schou
Jan 1, 1988·Clinical Allergy·J A Price, J L Longbottom
Jul 29, 1998·The Journal of Allergy and Clinical Immunology·R K BushP A Eggleston
Sep 18, 2013·Methods : a Companion to Methods in Enzymology·Ola B NilssonHans Grönlund
Mar 1, 2018·Frontiers in Immunology·Véronique SchultenAlessandro Sette

Related Concepts

Albumins
Allergens
Molecular Sieve Chromatography
Physical Dialysis
SDS-PAGE
Immunodiffusion Measurement
Immunoelectrophoresis
Leukocytes
Urine

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