Characterization of multiple-antibiotic-resistant Salmonella typhimurium stains: molecular epidemiology of PER-1-producing isolates and evidence for nosocomial plasmid exchange by a clone.

Journal of Clinical Microbiology
H VahabogluV Avkan

Abstract

We characterized epidemiologic and genetic features of nosocomially originated multiple-antibiotic-resistant Salmonella typhimurium isolates from two hospitals. A total of 32 multiply resistant strains, isolated during a 28-month period, were studied. Four resistance phenotypes were distinguished on the basis of the results of disc diffusion tests. Group 1 was resistant to chloramphenicol, gentamicin, tobramycin, amikacin, and the newer cephalosporins because of the production of an extended-spectrum beta-lactamase (PER-1). Group 2 exhibited the same pattern plus resistance to sulfamethoxazole-trimethoprim (Sxt). Except for Sxt resistance, dominant phenotypes of both groups were transferred on an identical plasmid, pSTI1 (81 MDa). Group 3 was resistant to ampicillin, chloramphenicol, gentamicin, tobramycin, and Sxt. This pattern was also transferred on an 81-MDa plasmid (pSTI2) which differed from pSTI1 on the basis of EcoRI and HindIII restriction fragments. Group 4 was resistant to ampicillin, chloramphenicol, and tetracycline, and a 74-MDa nonconjugative plasmid was detected. Restriction fragment length polymorphism of RNA-encoding DNA and arbitrarily primed PCR tests revealed that bacteria from groups 1, 2, and 3 were clona...Continue Reading

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Citations

Sep 29, 2005·Antimicrobial Agents and Chemotherapy·Gulcin G GacarHaluk Vahaboglu
Apr 18, 2007·Antimicrobial Agents and Chemotherapy·Pablo PowerGabriel Gutkind
Feb 15, 2001·The New England Journal of Medicine·J B BenderM T Osterholm
Jul 25, 2003·Antimicrobial Agents and Chemotherapy·Gerhard F WeldhagenPatrice Nordmann
Sep 30, 2005·Scandinavian Journal of Infectious Diseases·Aynur KaradenizliHaluk Vahaboglu
Apr 28, 2005·Antimicrobial Agents and Chemotherapy·Laurent PoirelPatrice Nordmann
Nov 16, 2010·Expert Review of Anti-infective Therapy·Esragul Akinci, Haluk Vahaboglu
Nov 19, 2002·Antimicrobial Agents and Chemotherapy·Betina E OrmanDaniela Centrón
Apr 23, 2002·Molecular Microbiology·Béatrice Hanau-BerçotEkkehard Collatz
Dec 15, 2010·Antimicrobial Agents and Chemotherapy·Delphine GirlichPatrice Nordmann
Jul 10, 2004·Journal of Clinical Microbiology·François-Xavier WeillPatrick A D Grimont
Jun 15, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·H Giamarellou
May 24, 2006·Microbes and Infection·Geovana Brenner MichaelStefan Schwarz
Feb 18, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Z AktaşP Nordmann
Feb 3, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C LlanesP Plésiat

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