Characterization of multiple nicotinic acetylcholine receptor-binding proteins and phospholipases A2 from the venom of the coral snake Micrurus nigrocinctus

FEBS Letters
A Alape-GirónT Bergman

Abstract

The presence of multiple nicotinic acetylcholine receptor (AchR)-binding proteins and phospholipases A2 was detected in the venom of a member of the Elapinae subfamily, Micrurus nigrocinctus nigrocinctus. Multi-step chromatographies were used to isolate four AchR-binding proteins (Mnn-9, Mnn-4, Mnn-3C and Mnn-1A) and five basic PLA2s (nigroxins A, B, C1, C2 and C3). The Micrurus AchR-binding proteins are antigenically and structurally related to short- and long-chain alpha-neurotoxins from Naja. The nigroxins are antigenically similar and constitute a new antigenic subclass of PLA(2)s. Nigroxins A and B are class I PLA(2)s, structurally more related to enzymes from Bungarinae than to those from Hydrophinae/Laticaudinae. These data contribute to clarify the relationships between Micrurus venom proteins and other elapid toxins and may be useful to improve the neutralizing efficiency of antivenoms.

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Citations

Jun 5, 2003·Toxicon : Official Journal of the International Society on Toxinology·Viviana ArceJosé María Gutiérrez
Apr 1, 1997·Toxicon : Official Journal of the International Society on Toxinology·A Alape-GirónJ M Gutiérrez
Jan 15, 1998·Toxicon : Official Journal of the International Society on Toxinology·E AmuyJ M Gutiérrez
Mar 19, 1999·Toxicon : Official Journal of the International Society on Toxinology·Z E Selvanayagam, P Gopalakrishnakone
Jan 23, 1999·European Journal of Biochemistry·A Alape-GirónH Jörnvall
Jan 22, 2014·Toxins·Alejandro Carbajal-SaucedoLéa Rodrigues-Simioni
Aug 2, 2011·Journal of Proteomics·Paula H C CiscottoAdriano M C Pimenta
Dec 7, 2007·Toxicon : Official Journal of the International Society on Toxinology·Elda E SánchezJohn C Pérez
Jan 25, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Alessandra L CecchiniAndreimar M Soares
Apr 6, 2016·Toxicon : Official Journal of the International Society on Toxinology·Gabriela D TanakaDenise V Tambourgi
Aug 22, 2013·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·A WoodR Weisman
Oct 29, 2013·Toxicon : Official Journal of the International Society on Toxinology·Melisa Bénard-ValleAlejandro Alagón
Dec 3, 2011·Toxicon : Official Journal of the International Society on Toxinology·Adolfo Rafael de RoodtRoberto Pablo Stock
Oct 30, 2016·Toxicon : Official Journal of the International Society on Toxinology·Bruno LomonteJuan J Calvete
Jul 19, 2006·Revista Do Instituto De Medicina Tropical De São Paulo·Fábio BucaretchiEduardo Mello de Capitani
Nov 13, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Aldo H UrdanetaJosé María Gutiérrez
Jun 25, 2004·Journal of Toxicology. Clinical Toxicology·Adolfo R de RoodtAlejandro Alagón
Dec 1, 2019·Toxicon : Official Journal of the International Society on Toxinology·Pedro Ferreira BisnetoIgor Luis Kaefer
Jul 28, 2020·Toxicon : Official Journal of the International Society on Toxinology·Pedro Ferreira BisnetoIgor Luis Kaefer
Jan 13, 2009·Toxicon : Official Journal of the International Society on Toxinology·José Christian DokmetjianMirtha Biscoglio de Jiménez Bonino

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