Characterization of multiple organ dysfunction syndrome in very low birthweight infants: a new sequential scoring system

Shock
J JanotaJ Simák

Abstract

To define multiple organ dysfunction in newborns, we established a sequential scoring system NEOMOD (Neonatal Multiple Organ Dysfunction Score). It was developed to describe the process of increasing physiologic derangement in critically ill newborns. It provides, during the first 28 days of life, information concerning function of organ systems having a primary influence on mortality in very low birth weight (VLBW) infants. Our scoring system has been used in 142 VLBW infants. It evaluates moderate (1 point) or severe dysfunction (2 points) in 7 organ systems (central nervous system, cardiovascular, renal, respiratory, and gastrointestinal systems, and hemocoagulation and acid-base balance) in 24-h intervals from day 1 to 28 of life. Maximum possible value of NEOMOD was 14 points. Receiver operating characteristic curve was used for assessing predictive accuracy of maximum NEOMOD score obtained by daily scoring for mortality rate. AUC (area under curve) attained by NEOMOD was 0.95 for mortality within the first 28 days and 0.91 for hospital mortality, respectively. In the study group, NEOMOD score of > or = 9 was associated with 100% mortality. An analysis of specific organ dysfunctions in the non-survivors group (n = 16) disc...Continue Reading

Citations

Dec 12, 2001·European Journal of Clinical Investigation·J JanotaJ Simák
Apr 29, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·William O Tarnow-Mordi
Feb 2, 2011·Journal of Veterinary Internal Medicine·K A HartD J Hurley
Mar 26, 2010·Journal of Perinatology : Official Journal of the California Perinatal Association·J MiletinE M Dempsey
Jul 30, 2010·Journal of Perinatology : Official Journal of the California Perinatal Association·S W Aucott
Jul 17, 2009·Acta Paediatrica·Doris FischerAlex Veldman
May 6, 2004·The Journal of Pediatrics·Joseph A JohnstonJoseph M Mrus
Mar 4, 2020·Pediatric Research·Matthew McGovernUNKNOWN Infection, Inflammation, Immunology and Immunisation (I4) section of the ESPR
Sep 4, 2012·American Journal of Critical Care : an Official Publication, American Association of Critical-Care Nurses·Merih CetinkayaHilal Özkan

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