PMID: 7539696Feb 1, 1995Paper

Characterization of muscarinic receptors mediating relaxation and contraction in the rat iris dilator muscle

British Journal of Pharmacology
Y MasudaM Watanabe

Abstract

1. The characteristics of muscarinic receptors mediating relaxation and/or contraction in the rat iris dilator muscle were examined. 2. Relaxation was induced in a dilator muscle by application of acetylcholine (ACh) at low doses (3 microM or less) and contraction was induced by high doses. Methacholine and carbachol also showed biphasic effects similar to those of ACh; in contrast, bethanechol, arecoline, pilocarpine and McN-A-343 induced mainly relaxation but no substantial contraction. 3. After parasympathetic denervation by ciliary ganglionectomy, the relaxant response to muscarinic agonists disappeared upon nerve stimulation. Application of McN-A-343 and pilocarpine induced only small contractions in denervated dilator muscles, indicating that these are partial agonists for contraction. 4. pA2 values of pirenzepine, methoctramine, AF-DX 116, himbacine, and 4-DAMP for antagonism to pilocarpine-induced relaxation in normal dilator muscles and those for antagonism to ACh-induced contraction in denervated dilator muscles were determined. The pA2 values for antagonism to relaxation of all these antagonists were most similar to those for M3-type muscarinic receptors. 5. Although pA2 values for contraction of these antagonists, e...Continue Reading

References

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Citations

Feb 1, 1995·British Journal of Pharmacology·N S YamaharaM Watanabe
May 31, 2012·Pharmacology & Therapeutics·Frederick J Mitchelson
Aug 12, 2014·Experimental Eye Research·Martin KronschlägerPer Söderberg
Jul 3, 2013·Peptides·Sara Azevedo-PintoAmândio Rocha-Sousa
May 6, 1999·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·X ZhangK A Erickson

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