Characterization of mutations in streptomycin-resistant Mycobacterium tuberculosis isolates in Sichuan, China and the association between Beijing-lineage and dual-mutation in gidB

Tuberculosis
Honghu SunQun Sun

Abstract

Mutations in rpsL, rrs, and gidB are well linked to streptomycin (STR) resistance, some of which are suggested to be potentially associated with Mycobacterium tuberculosis genotypic lineages in certain geographic regions. In this study, we aimed to investigate the mutation characteristics of streptomycin resistance and the relationship between the polymorphism of drug-resistant genes and the lineage of M. tuberculosis isolates in Sichuan, China. A total of 227 M. tuberculosis clinical isolates, including 180 STR-resistant and 47 pan-susceptible isolates, were analyzed for presence of mutations in the rpsL, rrs and gidB loci. Mutation K43R in rpsL was strongly associated with high-level streptomycin resistance (P < 0.01), while mutations in rrs and gidB potentially contributed to low-level resistance (P < 0.05). No general association was exhibited between STR resistance and Beijing genotype, however, in STR-resistant strains, Beijing genotype was significantly correlated with high-level STR resistance, as well as the rpsL mutation K43R (P < 0.01), indicating that Beijing genotype has an evolutionary advantage under streptomycin pressure. Notably, in all isolates of Beijing genotype, a dual mutation E92D (a276c) and A205A (a615g...Continue Reading

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Citations

Aug 28, 2016·International Journal of Antimicrobial Agents·Imen Ben-Kahla, Sahal Al-Hajoj
Apr 14, 2017·Journal of Global Antimicrobial Resistance·Azar Dokht KhosraviHamed Goodarzi
Jun 21, 2017·Médecine et maladies infectieuses·F BrossierUNKNOWN French National Reference Center for Mycobacteria(b)
Jan 18, 2018·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Noura M Al-MutairiEiman Mokaddas
Sep 14, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Majid Faridgohar
Jan 25, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Md Mahmudul IslamTianyu Zhang

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