Characterization of Myocardial Repolarization Reserve in Adolescent Females With Anorexia Nervosa

Circulation
Gareth J PadfieldAndrew D Krahn

Abstract

Patients with anorexia nervosa exhibit abnormal myocardial repolarization and are susceptible to sudden cardiac death. Exercise testing is useful in unmasking QT prolongation in disorders associated with abnormal repolarization. We characterized QT adaptation during exercise in anorexia. Sixty-one adolescent female patients with anorexia nervosa and 45 age- and sex-matched healthy volunteers performed symptom-limited cycle ergometry during 12-lead ECG monitoring. Changes in the QT interval during exercise were measured, and QT/RR-interval slopes were determined by using mixed-effects regression modeling. Patients had significantly lower body mass index than controls; however, resting heart rates and QT/QTc intervals were similar at baseline. Patients had shorter exercise times (13.7±4.5 versus 20.6±4.5 minutes; P<0.001) and lower peak heart rates (159±20 versus 184±9 beats/min; P<0.001). The mean QTc intervals were longer at peak exercise in patients (442±29 versus 422±19 ms; P<0.001). During submaximal exertion at comparable heart rates (114±6 versus 115±11 beats/min; P=0.54), the QTc interval had prolonged significantly more in patients than controls (37±28 versus 24±25 ms; P<0.016). The RR/QT slope, best described by a curvi...Continue Reading

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Citations

Nov 18, 2017·European Child & Adolescent Psychiatry·Monica BombaRenata Nacinovich
Oct 31, 2017·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Hugo GravelDaniel Curnier
Nov 8, 2017·The International Journal of Eating Disorders·Jason M NagataRebecka Peebles
Nov 26, 2021·Eating and Weight Disorders : EWD·Maria Rachele CeccariniMatteo Bertelli

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