Characterization of Nanoaerosol Size Change During Enhanced Condensational Growth.

Aerosol Science and Technology : the Journal of the American Association for Aerosol Research
P Worth LongestMichael Hindle

Abstract

Increasing the size of nanoaerosols may be beneficial in a number of applications including filtration, particle size selection, and targeted respiratory drug delivery. A potential method to increase particle or droplet size is enhanced condensational growth (ECG), which involves combining the aerosol with saturated or supersaturated air. In this study, we characterize the ECG process in a model tubular geometry as a function of initial aerosol size (mean diameters - 150, 560 and 900 nm) and relative humidity conditions using both in vitro experiments and numerical modeling. Relative humidities (99.8 - 104%) and temperatures (25 - 39 °C) were evaluated that can safely be applied to either targeted respiratory drug delivery or personal aerosol filtration systems. For inlet saturated air temperatures above ambient conditions (30 and 39 °C), the initial nanoaerosols grew to a size range of 1000 - 3000 nm (1 - 3 μm) over a time period of 0.2 seconds. The numerical model results were generally consistent with the experimental findings and predicted final to initial diameter ratios of up to 8 after 0.2 s of humidity exposure and 14 at 1 s. Based on these observations, a respiratory drug delivery approach is suggested in which nanoaer...Continue Reading

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Citations

Jun 26, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Kamrun NaharFakhrul Ahsan
Aug 2, 2011·Aerosol Science and Technology : the Journal of the American Association for Aerosol Research·P Worth Longest, Michael Hindle
Mar 18, 2011·Journal of Aerosol Medicine and Pulmonary Drug Delivery·P Worth LongestMichael Hindle
Jan 5, 2013·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Geng TianMichael Hindle
Jan 1, 2013·Journal of Aerosol Medicine and Pulmonary Drug Delivery·P Worth LongestMichael Hindle
Apr 3, 2012·Archivos de bronconeumología·Ana Fernández Tena, Pere Casan Clarà
Jun 7, 2011·Advanced Drug Delivery Reviews·P Worth Longest, Landon T Holbrook
Jun 17, 2014·Aerosol Science and Technology : the Journal of the American Association for Aerosol Research·Geng TianP Worth Longest
Feb 21, 2019·AAPS PharmSciTech·Chaeho MoonRobert O Williams
Oct 27, 2020·Aerosol Science and Technology : the Journal of the American Association for Aerosol Research·Patrick T O'ShaughnessyChing-Long Lin
Apr 30, 2020·Journal of Aerosol Science·Prathish K RajaramanChing-Long Lin
Mar 20, 2021·The Journal of Physical Chemistry. a·Matus E DivekyRuth Signorell

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Methods Mentioned

BETA
size fractionation

Software Mentioned

MathCAD

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