Characterization of nanostructure of stimuli-responsive polymeric composite membranes

Biomacromolecules
Kai ZhangXiao Yu Wu

Abstract

To elucidate the mechanism of stimuli-responsive permeability and to optimize the design, the nanostructure of polymeric composite membranes, developed in our laboratory, was characterized. The membranes were prepared to contain various amounts of stimuli-responsive nanoparticles of poly(N-isopropylacrylamide-co-methacrylic acid), with or without polyelectrolyte coating. Scanning electron microscopy and X-ray photoelectron spectroscopy were used respectively to examine the morphology and surface chemical composition, whereas atomic force microscopy and laser scanning confocal microscopy were employed to characterize the in situ surface and internal structure of the membranes in aqueous media of various pHs. The porous structure was evidenced in the presence of the nanoparticles. The surface content of the nanoparticles increased with increasing particle concentration while the polyelectrolyte coating was nearly undetectable. AFM images revealed that the particles in the membranes shrank with a concomitant increase in pore size as the buffer pH decreased. LSCM results indicated that particles were distributed through the membrane as interconnected clusters.

References

Mar 16, 2000·Journal of Biomaterials Science. Polymer Edition·J MoselhyK Kodaria
Mar 22, 2001·Advanced Drug Delivery Reviews·J Kost, R Langer
Apr 12, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kai Zhang, Xiao Yu Wu
Dec 4, 2002·Advanced Drug Delivery Reviews·Mads Kreilgaard

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Citations

Apr 9, 2013·Colloids and Surfaces. B, Biointerfaces·Sunita Prem Victor, Chandra P Sharma
Sep 10, 2011·Chemical Reviews·Qian WuZhefu Chen
Jul 2, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ronald A Siegel
Oct 27, 2015·Journal of Biomaterials Science. Polymer Edition·Yongli ShiNan Chen
May 19, 2011·Macromolecular Rapid Communications·Mark A HempeniusG Julius Vancso
Apr 24, 2007·Soft Matter·Paul A FitzGeraldErica J Wanless
Apr 18, 2006·Soft Matter·Shih-To FeiHarry R Allcock
Jan 30, 2018·International Journal of Pharmaceutics·Joel Coffel, Eric Nuxoll
Aug 20, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Paul A FitzgeraldErica J Wanless
Jun 19, 2021·ACS Applied Materials & Interfaces·Yu HoshinoIkuo Taniguchi

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