Characterization of natural hydroxyapatite originated from fish bone and its biocompatibility with osteoblasts

Materials Science & Engineering. C, Materials for Biological Applications
Pujie ShiMing Du

Abstract

Hydroxyapatite (HAP) was very attractive for using as bone implant material for a long period due to the close similarity with natural bone in composition and osteoconductive properties. In this study, three kinds of natural HAP (nHAP) derived from rainbow trout (Onchorynchus mkiss), cod (Gadus) and salmon (Oncorhynchus keta) bones were prepared using thermal calcination method for the first time. Resultant nHAPs were characterized by fourier transform infrared spectroscopy (FT-IR), x-ray diffraction analysis (XRD), field-emission scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) analysis. Biocompatibility of calcined nHAP was evaluated through MTT cell viability assay and alkaline phosphatase activity experiment using mouse preosteoblast MC3T3-E1. Results of cell experiment indicated that the nHAP originated from rainbow trout and salmon bones showed better biological compatibility compared with the nHAP originated from cod bone and chemical synthetic HAP (cHAP). This is most likely attributed to the different element composition in nHAP, i.e., the nHAP derived from rainbow trout and salmon bones showed the presence of CO32- and Mg2+. Therefore, the nHAP originated from rainbow trout and salmon bones ...Continue Reading

Citations

Aug 29, 2019·Chemical Society Reviews·Chunping XuRafael Luque
Oct 18, 2019·Materials·Muhammad Jamshaid ZafarZhengyan Zhang
May 31, 2019·Applied Biochemistry and Biotechnology·Amirhossein EsmaeilkhanianMohammad Irani
Oct 30, 2020·Scientific Reports·Yangli XuLaijin Su
Nov 4, 2020·International Journal of Molecular Sciences·Merve BasAnton Ficai
Apr 18, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Parthasarathy SuryaManupoori Sathish
May 4, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Satheesh Kumar BaluSampath V
Aug 14, 2020·Journal of Agricultural and Food Chemistry·Zhe XuMing Du
Aug 25, 2021·Journal of Materials Science. Materials in Medicine·Soo-Ling BeeZ A Abdul Hamid
Nov 16, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yanting LyuHiroshi Uyama

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