Characterization of neonatal rat morphine tolerance and dependence

European Journal of Pharmacology
S R ThorntonF L Smith

Abstract

The administration of morphine and fentanyl by continuous intravenous infusion has been shown to produce analgesic tolerance and physical dependence in human neonates. In animals, daily repeated morphine bolus injections is a common method of inducing neonatal rat tolerance and dependence. Yet this method differs from the intravenous route reported to affect human neonates. Alzet osmotic minipumps were implanted in postnatal day 14 rats to provide a continuous morphine infusion more closely mimicking the clinical picture. Rats remained naive or were infused with saline or morphine (0.7 mg/kg/h) for 72 h. Morphine's antinociceptive potency was similar between naive and saline-infused animals, while morphine-infused animals were tolerant. Gender did not contribute to the degree of tolerance observed. Naloxone precipitated withdrawal in the morphine pump-implanted rats was similar to that reported by others. Thus, minipumps provide a useful model for assessing the tolerance and dependence liability of different opioids.

References

Jun 1, 1978·British Journal of Pharmacology·A Auguy-ValetteG Pontonnier
Apr 29, 1992·European Journal of Pharmacology·G A Barr, S Wang
Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·J M Kiefel, R J Bodnar
May 24, 1991·Brain Research·Y Xia, G G Haddad
Apr 1, 1991·Pain·K L KeplerR J Bodnar
May 20, 1991·Brain Research. Developmental Brain Research·H Van Praag, H Frenk
Apr 6, 1990·Neuroscience Letters·S W BoldenL J Rogers
Nov 1, 1990·Toxicology Letters·I Kitchen, J A Boswell
Sep 1, 1987·The Journal of Pediatrics·M Yaster
Oct 1, 1988·Pharmacology, Biochemistry, and Behavior·M S Fanselow, C P Cramer
Dec 1, 1987·Anaesthesia·G Purcell-JonesE Sumner
Jan 1, 1986·Physiology & Behavior·C B Phifer, L M Terry
Jul 17, 1981·European Journal of Pharmacology·A Z Zhang, G W Pasternak
Jan 1, 1982·Biology of the Neonate·G Lapointe, G Nosal
Sep 1, 1993·The International Journal of Neuroscience·J S Meyer, A C Yacht
Jan 1, 1993·Journal of Pain and Symptom Management·C R McLaughlinW L Dewey
May 1, 1993·The Journal of Thoracic and Cardiovascular Surgery·M P LeuschenR M Nelson

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Citations

Mar 19, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Dusica BajicSulpicio G Soriano
Jan 9, 1999·European Journal of Pharmacology·S R Thornton, F L Smith
Jul 6, 2000·Pharmacology, Biochemistry, and Behavior·K L Jones, G A Barr
Feb 23, 2000·Pharmacology, Biochemistry, and Behavior·S R ThorntonF L Smith
Dec 13, 2000·Brain Research. Developmental Brain Research·A A McPhie, G A Barr
Apr 25, 2003·Brain Research. Developmental Brain Research·Hongbo ZhuCharles E Inturrisi
Aug 2, 2001·Trends in Pharmacological Sciences·H Zhu, G A Barr
Jul 11, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Susan L IngramMichael M Morgan
Nov 7, 2001·Paediatric Anaesthesia·S Suresh, K J Anand
Jun 7, 2003·The Clinical Journal of Pain·Rebecca M Craft
Aug 4, 2001·Behavioural Pharmacology·M Rodríguez-AriasV M Simón
Jun 26, 2004·Biology of the Neonate·Bhagya L PuppalaAnil Gulati
Apr 21, 2010·Pediatrics·Kanwaljeet J S AnandUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Resear
Oct 26, 2002·European Journal of Pharmacology·Geng-Chang YehChum-Lin Hu
May 23, 2007·International Journal of Pharmaceutics·Hoo-Kyun ChoiSeaung Youl Oh
Aug 27, 2009·Developmental Psychobiology·Anika A McPhie, Gordon A Barr
Oct 9, 2008·Acta Anaesthesiologica Scandinavica·Y KawaraguchiH Furuya
Apr 20, 2006·Seminars in Fetal & Neonatal Medicine·Sinno H P Simons, K J S Anand
Nov 19, 2005·Peptides·Bhagya L PuppalaAnil Gulati
Jul 31, 2004·Paediatric Anaesthesia·Dawn C Stoller, Forrest L Smith
Oct 7, 2004·European Journal of Pharmacology·Yukihiro Noda, Toshitaka Nabeshima
Jul 19, 2008·Anesthesia and Analgesia·Albert DahanElise Sarton
Jan 1, 2010·Therapeutic Drug Monitoring·Monique Moller, Gideon Koren
May 28, 2005·Anesthesia and Analgesia·Yan WangPamela Pierce Palmer
Sep 24, 2004·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Hongbo Zhu, Gordon A Barr
Jan 13, 2021·Cellular and Molecular Neurobiology·Nynke J van den HoogenTuan Trang

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