Characterization of neural cell lines derived from SV40 large T-induced primitive neuroectodermal tumors.

Brain Pathology
S WeggenO D Wiestler

Abstract

We recently reported intriguing properties of neural tumors generated by retrovirus-mediated transfer of the SV40 large T antigen into fetal rat brain transplants. Histopathologically, these neoplasms displayed characteristic features of primitive neuroectodermal tumors (PNET) and exhibited a striking potential for migration into the host brain. In the present study, four cell lines were derived from these PNETs and characterized. Two lines with an immature phenotype expressed the embryonal form of the neural cell adhesion molecule and nestin. They showed spheroid formation and delicate cell processes. The remaining cell lines had a flat, epitheloid appearance and were immunoreactive for synaptophysin, neurofilament proteins and glial fibrillary acidic protein. These cells constitute valuable tools to study the cellular origin(s) and molecular basis of PNETs, differentiation of neural progenitors and tumor cell migration in the brain.

References

May 1, 1992·Journal of Neuropathology and Experimental Neurology·D FultsR D McKay
Jan 1, 1989·Journal of Neuropathology and Experimental Neurology·X M HeD D Bigner
Sep 1, 1981·Journal of Virology·E HarlowN M Williamson
Oct 1, 1993·The Journal of Pathology·G CattorettiE Feudale
May 1, 1995·Journal of Neuropathology and Experimental Neurology·K M Fung, J Q Trojanowski
Aug 1, 1994·Critical Reviews in Oncology/hematology·W M Molenaar, J Q Trojanowski
Feb 1, 1994·Molecular and Chemical Neuropathology·J Q TrojanowskiV M Lee
Jul 1, 1993·Brain Pathology·P KleihuesB W Scheithauer
Feb 1, 1996·Current Opinion in Neurobiology·S Temple, X Qian

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Citations

Sep 15, 2005·Clinical & Experimental Metastasis·Alexandra CretuDeni S Galileo
Apr 28, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Gino R SomersPaul S Thorner
Jul 20, 2004·Clinical Microbiology Reviews·Regis A Vilchez, Janet S Butel
Dec 18, 2001·The Journal of Pathology·F J ReutherS Scheil
May 1, 2004·The Journal of Biological Chemistry·Sharon K ThomasRobert A Ross

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