Characterization of NFH-LacZ transgenic mice with the SHIRPA primary screening battery and tests of motor coordination, exploratory activity, and spatial learning

Behavioural Processes
R LalondeC Strazielle

Abstract

NFH-LacZ transgenic mice express a fusion protein between a truncated form of the endogenous neurofilament of heavy molecular weight and the complete E. coli beta-galactosidase. NFH-LacZ transgenic mice could be distinguished from controls in the SHIRPA neurological battery by the appearance of action tremor and hindlimb clasping and a lower body weight. Despite normal exploratory activity and spatial learning, NFH-LacZ transgenic mice were deficient in stationary beam, coat-hanger, and rotorod tests of motor coordination. These results are concordant with neuropathological findings in spinal motoneurons and the cerebellum and indicate that despite the absence of paralysis, these transgenic mice may serve as an experimental model of the early stage of amyotrophic lateral sclerosis.

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Citations

Jun 29, 2005·Brain Research Bulletin·R LalondeJ London
Oct 20, 2015·Behavior Genetics·Mohammed Filali, Robert Lalonde
Jun 30, 2009·Experimental Neurology·Jeremy M Shefner
Feb 22, 2005·Brain Research. Brain Research Protocols·Allan V Kalueff, Pentti Tuohimaa
Jul 15, 2015·Molecular Neurodegeneration·Carolina Ceballos-DiazNikolaus R McFarland
Feb 3, 2007·Behavioural Brain Research·R Lalonde, S Qian
Feb 3, 2004·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·Majid HafezparastElizabeth M C Fisher
Dec 25, 2004·Behavioural Brain Research·R LalondeC Strazielle
May 18, 2021·Current Protocols·Robert LalondeCatherine Strazielle

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