Characterization of novel plasmid-mediated β-lactamases (SHV-167 and ACT-16) associated with New Delhi metallo-β-lactamase-1 harbouring isolates from neonates in India

Journal of Medical Microbiology
Saswati DattaSulagna Basu

Abstract

Neonatal sepsis due to carbapenem-resistant bacteria is difficult to treat due to limited therapeutic options. The detection of the new carbapenemase New Delhi metallo-β-lactamase-1 (NDM-1) from neonates has further complicated the situation (Roy et al., 2011a). The potent metallo-β-lactamase NDM-1 efficiently hydrolyses all classes of β-lactam antibiotics (penicillins, cephalosporins and carbapenems) and is also associated with multiple determinants that enable the bacteria to become resistant to other antibiotic classes (Nordmann et al., 2011). In the presence of NDM-1 other β-lactamases may go unobserved because of the spectrum of activity of NDM-1 against all β-lactam antibiotics. Thus, under the canopy of the NDM-1 these β-lactamases also get the opportunity to spread. This communication reports association of two novel β-lactamases, SHV-type β-lactamase (SHV-167) and AmpC-type β-lactamase (ACT-16), in two NDM-1-carrying Enterobacteriaceae isolated from the blood of two septicaemic neonates admitted to a neonatal intensive care unit.

References

Jun 7, 2005·Journal of Microbiological Methods·Alessandra CarattoliE John Threlfall
Dec 10, 2008·Antimicrobial Agents and Chemotherapy·Hong Bin KimDavid C Hooper
Mar 12, 2011·The Journal of Antimicrobial Chemotherapy·Subhasree RoySulagna Basu
Aug 24, 2011·Antimicrobial Agents and Chemotherapy·Laurent PoirelPatrice Nordmann
Nov 15, 2011·Trends in Microbiology·Patrice NordmannDavid M Livermore
Jan 19, 2012·Antimicrobial Agents and Chemotherapy·Sally R PartridgeJonathan R Iredell

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Citations

Jan 19, 2017·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Samia HammamiIlhem Boutiba-Ben Boubaker
Jun 29, 2021·Frontiers in Medicine·Subhankar MukherjeeSulagna Basu

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