Characterization of oculomotor and visual activities in the primate pedunculopontine tegmental nucleus during visually guided saccade tasks

The European Journal of Neuroscience
Ken-Ichi Okada, Yasushi Kobayashi

Abstract

The pedunculopontine tegmental nucleus (PPTN) has anatomical connections with numerous visuomotor areas including the basal ganglia, thalamus, superior colliculus and frontal eye field. Although many anatomical and physiological studies suggest a role for the PPTN in the control of conditioned behavior and associative learning, the detailed characteristics of saccade- and visual-related activities of PPTN neurons remain unclear. We recorded the activity of PPTN neurons in monkeys (Macaca fuscata ) during visually guided saccade tasks, and examined the response properties of saccade- and visual-related activities such as time course, direction selectivity and contextual modulation. Saccade-related activity occurred either during saccade execution or after saccade end. The preferred directions of the neuronal activity were biased toward the contralateral and upward sides. Half of the saccade-related neurons showed activity modulation only for task saccades and not for spontaneous saccades outside the task. Visually-responsive neurons responded with short latencies. Some responded to the appearance of the visual stimulus in a directionally selective manner, and others responded to both the appearance and disappearance of the visua...Continue Reading

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Citations

Aug 4, 2015·Behavioural Brain Research·Yukiko OguraToshiya Matsushima
Jun 8, 2011·The European Journal of Neuroscience·Masayuki Watanabe, Douglas P Munoz
May 28, 2014·The European Journal of Neuroscience·Ken-ichi Okada, Yasushi Kobayashi
Mar 15, 2015·Brain : a Journal of Neurology·Brian LauCarine Karachi
Jul 10, 2020·The European Journal of Neuroscience·Maja Klarendic, Diego Kaski
Jul 24, 2015·Journal of Neurophysiology·Andrew B WolfGidon Felsen

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