Characterization of orbital masses by multiparametric MRI

European Journal of Radiology
Sa-Ra RoKatharina Erb-Eigner

Abstract

DWI and dynamic contrast enhanced (DCE) MR imaging are techniques that allow insight to tumor vascularity and cellularity. We evaluated the diagnostic performance of multiparametric MRI (mp-MRI) in distinguishing benign from malignant orbital masses using standard anatomic imaging (sAI), DWI and DCE. This prospective IRB approved study with written informed consent included 65 patients. mp-MRI at 3 Tesla including DWI and DCE was performed in all patients. Parametric maps were generated for obtaining the perfusion parameters including K(trans), kep, ve and iAUC and time-signal intensity curves were recorded to determine the curve pattern. Two radiologists rated the likelihood of malignancy on a five-point scale in three separate, randomized reading sessions (initially only sAI, afterwards sAI+either DWI or DCE and finally sAI+DWI+DCE). Data was statistically analyzed. 33 Patients had malignant orbital masses and 32 patients had benign orbital masses (reference standard histopathology in 35 cases and clinical follow-up in 30 patients). The mean ADC of malignant masses differed significantly from the mean (SD) ADC of benign masses (0.825 [0.437]×10(-3)mm(2)/s and 1.257 [0.576]×10(-3)mm(2)/s, respectively) (p=0.001). K(trans), kep...Continue Reading

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Citations

Jun 15, 2016·Journal of Magnetic Resonance Imaging : JMRI·Xiao-Quan XuFei-Yun Wu
Jul 9, 2016·European Journal of Radiology·Patrick Asbach
Jul 12, 2016·European Journal of Radiology·A LeclerL Fournier
Jul 6, 2018·The British Journal of Radiology·Mitsuteru TsuchiyaHarumi Sakahara
Apr 17, 2019·Journal of Magnetic Resonance Imaging : JMRI·Augustin LeclerLaure Fournier
Oct 1, 2019·International Ophthalmology Clinics·Liza M Cohen, Michael K Yoon
Nov 17, 2019·Endocrine·Lukasz KamieniarzChristos Toumpanakis
Apr 17, 2020·Seminars in Ophthalmology·Camilla RussoAndrea Elefante
Aug 3, 2020·European Radiology·Augustin LeclerLaure Fournier
Oct 14, 2017·AJNR. American Journal of Neuroradiology·R RathoreA Chandra
Dec 10, 2016·Cardiovascular and Interventional Radiology·Faramarz EdalatAfshin Gangi
Sep 21, 2018·Neuroradiology·Paolo GalluzziThedora Hadjistilianou
May 28, 2017·Japanese Journal of Radiology·Bo Sun, Liyuan Song
Feb 5, 2021·Current Eye Research·Thoralf NiendorfOliver Stachs
Jun 1, 2021·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Rebecca E TanenbaumSara T Wester
Jul 29, 2021·The Indian Journal of Radiology & Imaging·Preeti MundhadaDhananjay Raje

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