Characterization of ovolin, an orally active tryptic peptide released from ovalbumin with anxiolytic-like activity

Journal of Neurochemistry
Ayako OdaKousaku Ohinata

Abstract

We found that tryptic digest of ovalbumin after oral (p.o.) and intraperitoneal (i.p.) administration exhibited anxiolytic-like activity in mice, and then searched for orally active low-molecular-weight peptides with anxiolytic-like activity in the tryptic digest. Val-Tyr-Leu-Pro-Arg, named ovolin, corresponding to ovalbumin (280-284), mimicked the anxiolytic-like activity after p.o. and i.p. administration. The anxiolytic-like activity of ovolin was inhibited by indomethacin, a cyclooxygenase (COX) inhibitor, or BWA868C, an antagonist of the DP1 receptor for prostaglandin (PG) D2 . Ovolin-induced anxiolytic-like activity was also blocked by SCH58261 or bicuculline, antagonists of the adenosine A2A and GABAA receptors, respectively. Ovolin has no affinity for the DP1 , A2A and GABAA receptors. Taken together, ovolin may exhibit anxiolytic-like activity in a manner dependent on the PGD2 -DP1 system coupled to the A2A and GABAA receptors.

References

Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R UenoO Hayaishi
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·Y UradeO Hayaishi
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·S SatohO Hayaishi
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·N EguchiO Hayaishi
Nov 30, 2006·Current Opinion in Pharmacology·Zhi-Li HuangOsamu Hayaishi
Oct 12, 2007·Bioscience, Biotechnology, and Biochemistry·Kousaku OhinataMasaaki Yoshikawa
Feb 9, 2008·FEBS Letters·Kousaku OhinataMasaaki Yoshikawa
Nov 15, 2008·Prostaglandins & Other Lipid Mediators·Hui ZhaoMasaaki Yoshikawa
Dec 8, 2010·Journal of Agricultural and Food Chemistry·Hideo Kaneko

❮ Previous
Next ❯

Citations

Apr 5, 2016·International Journal of Molecular Sciences·Lakshmi A DaveShane M Rutherfurd
May 10, 2015·Neuropeptides·Yukako YamamotoKousaku Ohinata
Apr 11, 2013·Neuroscience Letters·Takafumi MizushigeKousaku Ohinata
Sep 17, 2013·Molecular Nutrition & Food Research·Ayako YamadaKousaku Ohinata
Apr 13, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Takafumi MizushigeKousaku Ohinata
Oct 4, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yukiha MoriKousaku Ohinata
Feb 3, 2021·Food & Function·Zeeshan HafeezLaurent Miclo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.