Characterization of oxytocin actions in guinea-pig isolated uterine artery: the effect of pregnancy

European Journal of Pharmacology
A JovanovićL Grbović

Abstract

While the contractile effect of oxytocin on uterine artery has been reported, little is known about whether pregnancy affects the responsiveness of this artery to oxytocin. If it does, is it a consequence of changed endothelial function, as has been proposed for some other vasoconstrictors. Furthermore, the receptor subtypes involved in oxytocin action on uterine artery has not been yet determined. Therefore the purposes of this study were to (1) determine the receptor subtypes involved in oxytocin action in non-pregnant and pregnant guinea-pig uterine artery and to (2) determine whether possible changes in uterine artery sensitivity to oxytocin during pregnancy are due to altered endothelial function. Therefore, the effect of oxytocin on non-pregnant and pregnant guinea-pig uterine arterial rings with and without endothelium was investigated. In non-pregnant guinea-pig uterine artery oxytocin induced contraction (pEC50 = 7.63) with greater potency than in pregnant guinea-pig uterine artery (pEC50 = 7.17). Removal of the endothelium did not affect oxytocin-induced contractions, regardless of the pregnancy status. The uterine arteries did not respond to [Thr4, Gly7]oxytocin. In the preparations studied, [d(CH2)5Tyr(Me)2]vasopres...Continue Reading

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Citations

Jan 4, 2006·American Journal of Obstetrics and Gynecology·Yuri P VedernikovRobert E Garfield
Dec 23, 2003·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·H LiP Olofsson
Jul 13, 1999·Human Reproduction·S JovanovićA Jovanović
Mar 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·M E MillerB F Mitchell

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