Characterization of patients at high risk of melanoma in Austria

The British Journal of Dermatology
C MüllerIchiro Okamoto

Abstract

Risk of melanoma is determined by genetic and exogenous factors. Only a few studies have included both characteristics in a comprehensive multivariable analysis. To find determinants of patients at high risk of melanoma in Austria, including phenotype, genotype and lifestyle characteristics in comprehensive analyses. In total, 1668 patients with melanoma from the M3 case-control study were studied. Overall, 567 participants were sequenced for CDKN2A, 232 for CDK4, 123 for MITF encoding the variant E318K and 964 for MC1R. Patients with melanoma with a positive family history (n = 190, 11·6%), multiple primary melanomas (n = 261, 15·7%) and younger age (< 50 years, n = 675, 40·5%) were defined as being at high risk. All other patients with melanoma were defined as the reference group. We found significant differences between those two groups and between the high-risk subgroups (positive family history, multiple primary melanomas and younger age). Pigmentation phenotype was associated with the high-risk group in general (childhood freckling, odds ratio 1·46, P = 0·007; blond/reddish hair colour, odds ratio 1·43, P = 0·011). Patients with a positive family history and patients with early-onset disease were similar regarding both th...Continue Reading

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Citations

Jun 19, 2016·The British Journal of Dermatology·I Stefanaki, A J Stratigos
Jan 24, 2018·The British Journal of Dermatology·S VerykiouD Hill
Jun 14, 2018·JAMA Dermatology·Judith WendtIchiro Okamoto
Nov 11, 2018·International Journal of Cancer. Journal International Du Cancer·Thomas P PotjerUNKNOWN Dutch Working Group for Clinical Oncogenetics
Mar 11, 2018·G3 : Genes - Genomes - Genetics·Christoph MüllerIchiro Okamoto
Dec 20, 2018·JAMA Dermatology·Christoph MüllerIchiro Okamoto

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