Characterization of patterns of expression of protein kinase C-alpha, -delta, -eta, -gamma and -zeta and their correlations to p53, galectin-3, the retinoic acid receptor-beta and the macrophage migration inhibitory factor (MIF) in human cholesteatomas

Hearing Research
R GhanooniG Choufani

Abstract

Cholesteatoma is a benign disease characterized by the presence of an unrestrained growth and the accumulation of keratin in the middle ear cavity. Due to roles in cell proliferation, apoptosis and differentiation members of the protein kinase C (PKC) family could be involved in disease progression. This study focuses on the expression of protein kinase C-alpha, -delta, -eta, -gamma and -zeta in the epithelial tissues of 56 human cholesteatomas and their correlations with those of previously characterized distributions of p53, galectin-3, retinoic acid receptor-beta (RARbeta) and macrophage migration inhibitory factor (MIF). We have previously reported this marker set to be correlated with keratinocyte differentiation in human cholesteatomas. Our present data clearly show that the percentage of PKC-alpha (but not PKC-delta, -gamma, -eta and -zeta)-immunopositive cells in epithelial tissue fro recurrent cholesteatomas was significantly higher than in non-recurrent cases. Correlations between the PKC isoenzymes and the biological markers were non-uniform. PKC-alpha (but not PKC-delta, -gamma, -eta and -zeta) expression in epithelial cholesteatoma cells correlated significantly and positively with the percentages of p53-immunoposi...Continue Reading

References

Jul 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G J Fisher, J J Voorhees
Feb 1, 1997·European Journal of Biochemistry·H J Gabius
Jul 1, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J Hofmann
Apr 3, 1998·Archives of Otolaryngology--head & Neck Surgery·H KojimaH Moriyama
Aug 24, 1999·Reviews of Physiology, Biochemistry and Pharmacology·M D Swope, E Lolis
Nov 24, 1999·The Journal of Experimental Medicine·C Cordon-Cardo, C Prives
Feb 23, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S Jaken, P J Parker
Sep 12, 2002·Biochimica Et Biophysica Acta·Gabriel A RabinovichMarta A Toscano
May 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hugues LegendreRobert Kiss
Apr 30, 2004·Glycoconjugate Journal·Harald LahmHans-Joachim Gabius
Jun 3, 2004·Chembiochem : a European Journal of Chemical Biology·Hans-Joachim GabiusHarold Rüdiger

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Citations

Jan 6, 2009·Veterinary Surgery : VS·Elizabeth M HardieAnthony P Pease
Feb 1, 2012·The Journal of International Medical Research·X Chen, Z Qin
Apr 18, 2013·Asian Pacific Journal of Tropical Biomedicine·Pachaiyappan Saravana KumarSavarimuthu Ignacimuthu

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