Characterization of periplastidal compartment-targeting signals in chlorarachniophytes

Molecular Biology and Evolution
Yoshihisa HirakawaKen-ichiro Ishida

Abstract

Secondary plastids are acquired by the engulfment and retention of eukaryotic algae, which results in an additional surrounding membrane or pair of membranes relative to the more familiar primary plastids of land plants. In most cases, the endocytosed alga loses its eukaryotic genome as it becomes integrated, but in two algal groups, the cryptophytes and chlorarachniophytes, the secondary plastids retain a vestigial nucleus in the periplastidal compartment (PPC), the remnant eukaryotic cytoplasm between the inner and the outer membrane pairs. Many essential housekeeping genes are missing from these reduced genomes, suggesting that they are now encoded in the host nucleus and their products are targeted to the PPC. One such nucleus-encoded, PPC-targeted protein, the translation elongation factor like (EFL) was recently identified in chlorarachniophytes. It bears an N-terminal-targeting sequence comprising a signal peptide and a transit peptide-like sequence (TPL) similar to the plastid-targeted proteins of chlorarachniophytes as well as a hydrophilic C-terminal extension rich in lysine and aspartic acid. Here, we characterize the function of the N- and C-terminal extensions of PPC-targeted EFL in transformed chlorarachniophyte c...Continue Reading

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Citations

Dec 12, 2012·Genome Biology and Evolution·Julia F HopkinsJohn M Archibald
Mar 5, 2013·Annual Review of Plant Biology·Patrick J Keeling
Apr 8, 2011·Molecular Microbiology·Yoshihisa HirakawaPatrick J Keeling
Nov 5, 2010·The Plant Journal : for Cell and Molecular Biology·Yoshihisa Hirakawa, Ken-ichiro Ishida
Jun 12, 2012·Biochimica Et Biophysica Acta·Lilach Sheiner, Boris Striepen
Feb 5, 2019·Genome Biology and Evolution·Nicholas A T Irwin, Patrick J Keeling
Dec 4, 2012·Nature·Bruce A CurtisJohn M Archibald
Aug 10, 2016·Genome Biology and Evolution·Shigekatsu SuzukiYoshihisa Hirakawa
Oct 6, 2012·Journal of Cell Science·Yoshihisa HirakawaPatrick J Keeling

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