Characterization of Physiologic (18)F FSPG Uptake in Healthy Volunteers

Radiology
Camila MosciErik S Mittra

Abstract

Purpose To evaluate the normal biodistribution and kinetics of (S)-4-(3-[18F]fluoropropyl)-l-glutamic acid ((18)F FSPG) in healthy volunteers and to compare (18)F FSPG mean and maximum standardized uptake values (SUVmean and SUVmax, respectively) with those of (18)F fluorodeoxyglucose (FDG) across a variety of organs. Materials and Methods This protocol was reviewed and approved by all appropriate regulatory authorities. An 8-mCi (±10%) dose of (18)F FSPG was given to five subjects (three women, two men), and seven whole-body positron emission tomography (PET) scans were performed 5, 10, 20, 30, 45, 150, and 240 minutes after injection. Regions of interest were analyzed on the resultant (18)F FSPG images to evaluate the kinetics of this radiotracer. The images obtained 45 minutes after injection were used to measure SUVmean and SUVmax in additional regions of the body. These values were compared with similar values obtained with (18)F FDG PET published previously. Descriptive statistics, including average and standard deviation across the five subjects, were used. (18)F FSPG SUVmean and SUVmax were compared. Results On the (18)F FSPG images obtained 45 minutes after injection, there was only low-grade background activity in the...Continue Reading

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Citations

Nov 28, 2012·The Veterinary Clinics of North America. Equine Practice·Kurt Selberg, Michael Ross
Oct 28, 2017·Clinical Nuclear Medicine·Meaghan A MagarikPierre P Massion
Jul 23, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sonya Youngju ParkErik S Mittra
Feb 25, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Lin ZhuHank F Kung
May 21, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Richard EdwardsTimothy H Witney

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