Characterization of phyto-nanoparticles from Ficus krishnae for their antibacterial and anticancer activities

Drug Development and Industrial Pharmacy
Amarvani P KanjikarRamesh L Londonkar

Abstract

Ovarian cancer is deadliest of fifth leading cause of death in women worldwide. This is due to advanced-stage disease rate associated with the development of chemoresistance. Hence, the current study emphasizes the process of synthesis of silver nanoparticles (AgNPs) from green chemistry method. Ficus krishnae is a perennial plant, native to India, used in folklore medicine to treat various diseases. For the development of reliable, ecofriendly, less expensive process for the synthesis of AgNPs against bacterial and ovarian cancer. The synthesis of silver nanoparticles from stem bark of Ficus krishnae was carried out. The synthesized nanoparticles are subjected by UV-Vis spectrophotometer, scanning electron microscopy (SEM), X-ray diffraction (XRD) analysis and FTIR analysis. The antibacterial efficacy also determined by disc diffusion method, MIC, CFU and growth curve. In vitro cytotoxicity effect of aqueous extract and AgFK nanoparticle in ovarian cancer cell line by MTT assay was performed. The formation of AgNPs was confirmed by UV-VIS spectroscopic absorbance shown that peak at 435 nm. XRD photograph has indicated the face-centered cubic structure of the synthesized AgNPs. SEM study demonstrated that the size from 160 to 2...Continue Reading

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Citations

Jun 9, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sin-Yeang TeowKamyar Shameli
Dec 5, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ema BurlacuLavinia Berta
Jun 6, 2018·Materials·Gregory MarslinGregory Franklin
Nov 25, 2020·Journal of Medicinal Chemistry·Mariana MoraisJoão A V Prior

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