Characterization of polysaccharides with antioxidant and immunological activities from Rhizoma Acori Tatarinowii

Carbohydrate Polymers
Wuxia ZhangJinyou Duan

Abstract

Rhizoma Acori Tatarinowii is widely used in traditional Chinese medicine. In this study, three novel polysaccharides designated RATPW, RATPS1 and RATPS2 were isolated from Rhizoma Acori Tatarinowii by DEAE-52 cellulose chromatography. Their structures were characterized using physicochemical and spectral methods. Chemical analysis indicated that RATPW (6.5×10(3)Da) mainly composed of glucose and fructose. RATPS1 (1.5×10(5)Da) contained galactose and arabinose, while RATPS2 (5.3×10(4)Da) contained ∼49.5% galacturonic acid along with rhamnose, fructose, galactose, and arabinose. In vitro, RATPS2 showed the most significant scavenging activity on DPPH and hydroxyl radical. Three polysaccharides could protect the PC12 cells from H2O2-induced damage. Immunological tests indicated that both RATPW and RATPS2 significantly stimulated NO production and phagocytic activity in RAW264.7, and promoted splenocyte proliferation. These data suggested that polysaccharides RATPW and RATPS2 had the potential as novel natural sources of antioxidative and immunopotentiating agents.

References

Aug 1, 1973·Analytical Biochemistry·N Blumenkrantz, G Asboe-Hansen
Jan 1, 1995·Journal of Pineal Research·R J ReiterD Acuña-Castroviejo
Aug 23, 2001·International Immunopharmacology·J W Coleman
Dec 1, 2001·Free Radical Biology & Medicine·J Nordberg, E S Arnér
Nov 26, 2002·Trends in Neurosciences·Edzard Ernst
Oct 3, 2003·Journal of Ethnopharmacology·A ManosroiJ Manosroi
Dec 31, 2003·Bioorganic & Medicinal Chemistry·F CerqueiraM S J Nascimento
Mar 24, 2004·Journal of Ethnopharmacology·Eun Mi ChoiJae-Kwan Hwang
Sep 30, 2004·International Immunopharmacology·P K Raveendran NairCheppail Ramachandran
Mar 16, 2005·Analytical Biochemistry·Tatsuya MasukoYuan C Lee
Mar 31, 2005·Carbohydrate Research·Jimmy Tai-Nin ChowWarren J Goux
Nov 9, 2005·International Immunopharmacology·Igor A SchepetkinMark T Quinn
Jan 24, 2006·International Immunopharmacology·Igor A Schepetkin, Mark T Quinn
Jun 27, 2006·Fitoterapia·A Kardosová, E Machová
Jul 25, 2006·European Journal of Pharmacology·D Allan ButterfieldRukhsana Sultana
May 8, 2008·Bioscience, Biotechnology, and Biochemistry·Sang-Myeon LeeHae-Ryong Park
May 5, 2010·Journal of Agricultural and Food Chemistry·Xingbin YangYan Zhao
Oct 30, 2010·Glycobiology·Jinyou Duan, Dennis L Kasper
May 18, 2011·Current Opinion in Rheumatology·Jinyou Duan, Dennis L Kasper
Jan 11, 2012·International Journal of Biological Macromolecules·Yuanfeng WangXinlin Wei
Dec 12, 2012·Glycoconjugate Journal·Wuxia ZhangShunchun Wang
Apr 1, 2014·International Journal of Biological Macromolecules·Jie JiangRui Zhou

❮ Previous
Next ❯

Citations

Jul 3, 2016·International Journal of Biological Macromolecules·Qiaohong HanMing Yuan
Nov 5, 2016·International Journal of Biological Macromolecules·Qihong ZhangWeike Su
Oct 30, 2016·International Journal of Biological Macromolecules·Liu TangGanggang Shi
Dec 6, 2016·International Journal of Molecular Sciences·Jinzhe HePeilong Sun
Sep 21, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Yang Liu, Gangliang Huang
Jan 20, 2021·International Journal of Biological Macromolecules·Prasenjit MaityGajendra Nath Maity

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis