Characterization of poly(vinyl acetate) based floating matrix tablets

Journal of Controlled Release : Official Journal of the Controlled Release Society
Sandra StrübingKarsten Mäder

Abstract

Floating Kollidon SR matrix tablets containing Propranolol HCl were developed and characterized with respect to drug release characteristics and floating strength. Kollidon SR was able to delay Propranolol HCl release efficiently. Drug release kinetics was evaluated using the Korsmeyer-Peppas model and found to be governed by Fickian diffusion. Tablet floating started immediately and continued for 24 h. It was possible to monitor the floating strength of the matrix devices using a simple experimental setup. Floating strength was related to Kollidon SR level with improved floating characteristics for samples with a high polymer/drug ratio. Swelling characteristics of the tablets were analyzed by applying the equation according to Therien-Aubin et al. The influence of the polymer content on swelling characteristics was found to be only marginal. Furthermore, the new method of benchtop MRI was introduced to study the water diffusion and swelling behaviour non-invasively and continuously.

References

Feb 17, 2000·International Journal of Pharmaceutics·S BaumgartnerB Zorko
Jul 29, 2000·Drug Development and Industrial Pharmacy·A O Nur, J S Zhang
Aug 23, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·J WangK Morimoto
Feb 28, 2002·Biomacromolecules·Wilms E BailleRobert H Marchessault
Nov 12, 2002·Biomacromolecules·Cédric MalveauRobert H Marchessault
Jan 30, 2003·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·A StreubelR Bodmeier
Jan 22, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sasa BaumgartnerJulijana Kristl
Jun 15, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·H KranzJ Reinhard
Aug 12, 2005·Drug Development and Industrial Pharmacy·A K SrivastavaB Mishra
Nov 15, 2005·Biomacromolecules·Héloïse Thérien-AubinRobert H Marchessault
Dec 14, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Riikka MäkiJarkko Ketolainen
Sep 7, 2006·Drug Development and Industrial Pharmacy·E Cedillo-RamírezA Hernández-León

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Citations

Aug 30, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Julia GrundRoland Bodmeier
Feb 5, 2009·Tissue Engineering. Part C, Methods·Hagen NitzscheKarsten Mäder
Sep 29, 2011·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Canan HasçiçekNurten Ozdemir
Sep 6, 2014·Drug Development and Industrial Pharmacy·Yunyun GaoXinggang Yang
Feb 2, 2013·Drug Development and Industrial Pharmacy·Shilpa Raut Desai, Bhagwan D Rohera
Jun 3, 2015·Drug Development and Industrial Pharmacy·Nizar Al-ZoubiStavros Malamataris
Apr 22, 2011·Expert Opinion on Drug Delivery·Khosro AdibkiaYousef Javadzadeh
Apr 25, 2012·International Journal of Pharmaceutics·Chungang ZhangXing Tang
Nov 19, 2011·Drug Discovery Today·Przemysław P DorożyńskiGreg J Stanisz
Dec 1, 2010·International Journal of Pharmaceutics·M D Mantle
Oct 13, 2010·International Journal of Pharmaceutics·Friederike EisenächerKarsten Mäder
Apr 27, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ursa MikacSasa Baumgartner
Nov 12, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ray-Neng ChenMing-Thau Sheu
Sep 10, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·F SiepmannJ Siepmann
May 2, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Işik OzgüneyRoland Bodmeier
Jan 17, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Susanne MuschertJuergen Siepmann
Oct 22, 2008·International Journal of Pharmaceutics·Hendrik Metz, Karsten Mäder
Oct 9, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Vincent MalaterreKarsten Mäder
Sep 3, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·J NunthanidS Puttipipatkhachorn
Aug 8, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Péter DiósAttila Dévay
Jul 23, 2011·Journal of Experimental & Clinical Cancer Research : CR·Henrike CaysaThomas Mueller
Jul 26, 2019·AAPS PharmSciTech·Rana AmayrehAlberto Berardi
Dec 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Prasanna Lakshmi AbbarajuChengzhong Yu

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