Characterization of premorbid functioning during childhood in patients with deficit vs. non-deficit schizophrenia and in their healthy siblings

Schizophrenia Research
Paola BucciMario Maj

Abstract

Impaired premorbid adjustment has been reported in patients with schizophrenia, generally in association with unfavorable aspects of the illness (e.g., poor outcome and severe negative symptoms). Several studies attempted to define the domains of premorbid dysfunction associated with negative symptoms and poor outcome; however, most of them assessed broadly defined negative symptoms. The present study was aimed to characterize premorbid functioning in a group of patients with deficit schizophrenia (DS), characterized by the presence of at least two primary and persistent negative symptoms (PPNS), and one of patients with a diagnosis of schizophrenia who did not meet criteria for DS (NDS). The presence of emotional/behavioral problems during childhood was investigated using the Childhood Behavior Checklist (CBCL) in both patient groups and in their respective healthy siblings. The Premorbid Adjustment Scale (PAS) was also used to assess premorbid functioning during childhood in the two patient groups. PPNS were also treated as a continuous variable and correlated with the indices of premorbid functioning regardless the DS/NDS categorization. DS patients, as compared to NDS, showed higher scores on the CBCL subscale "Withdrawn". ...Continue Reading

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Citations

Jun 1, 2016·Schizophrenia Research·Armida MucciSilvana Galderisi
Feb 18, 2017·Current Opinion in Psychiatry·Paola Bucci, Silvana Galderisi
Sep 12, 2019·Journal of the International Neuropsychological Society : JINS·Margherita BechiMarta Bosia
Jun 3, 2017·Schizophrenia Bulletin·Brian KirkpatrickSilvana Galderisi
Jul 10, 2018·Acta Psychiatrica Scandinavica·P BucciUNKNOWN Italian Network for Research on Psychoses
Apr 10, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Johanna Seitz-HollandMarek Kubicki

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